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High Expression Level of Tra2-β1 Is Responsible for Increased SMN2 Exon 7 Inclusion in the Testis of SMA Mice

Spinal muscular atrophy (SMA) is an inherited neuromuscular disease caused by deletion or mutation of SMN1 gene. All SMA patients carry a nearly identical SMN2 gene, which produces low level of SMN protein due to mRNA exon 7 exclusion. Previously, we found that the testis of SMA mice (smn(−/−) SMN2)...

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Detalles Bibliográficos
Autores principales:	Chen, Yu-Chia, Chang, Jan-Gowth, Jong, Yuh-Jyh, Liu, Ting-Yuan, Yuo, Chung-Yee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363149/ https://www.ncbi.nlm.nih.gov/pubmed/25781985 http://dx.doi.org/10.1371/journal.pone.0120721

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