Cargando…
Medication Adherence and Health Outcomes of People Living with HIV Who Are Food Insecure and Prescribed Antiretrovirals That Should Be Taken with Food
INTRODUCTION: Food insecurity is a well-established predictor of poor health outcomes. Antiretroviral therapies (ARTs) that should be taken with food to increase bioavailability may further challenge food insecure patients. This study examined factors associated with antiretroviral adherence and HIV...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363219/ https://www.ncbi.nlm.nih.gov/pubmed/25613643 http://dx.doi.org/10.1007/s40121-015-0057-y |
_version_ | 1782361889498464256 |
---|---|
author | Kalichman, Seth C. Washington, Christopher Grebler, Tamar Hoyt, Ginger Welles, Brandi Kegler, Christopher Kalichman, Moira O. Cherry, Chauncey |
author_facet | Kalichman, Seth C. Washington, Christopher Grebler, Tamar Hoyt, Ginger Welles, Brandi Kegler, Christopher Kalichman, Moira O. Cherry, Chauncey |
author_sort | Kalichman, Seth C. |
collection | PubMed |
description | INTRODUCTION: Food insecurity is a well-established predictor of poor health outcomes. Antiretroviral therapies (ARTs) that should be taken with food to increase bioavailability may further challenge food insecure patients. This study examined factors associated with antiretroviral adherence and HIV viral suppression among people living with HIV who are food insecure and prescribed medications that require food. METHODS: A community sample of 313 men and 105 women who experienced food insecurity in the previous month and were currently taking ART completed computerized interviews, urine screening for drug use, prospective biweekly unannounced pill count adherence assessments, and obtained their HIV viral load and CD4 cell counts from medical records. RESULTS: Individuals taking ART regimens that should be taken with food were significantly more likely to be unemployed, were living longer with an HIV diagnosis, had lower CD4 cell counts, poorer HIV suppression, and endorsed more beliefs that taking medications was necessary for their health. Multivariable regression models controlling for potential confounding factors showed that receiving ART that requires food was significantly related to poorer ART adherence and unsuppressed HIV in this food insecure sample. CONCLUSION: People living with HIV who are food insecure likely experience multiple facets of poverty that challenge their medication adherence, but food insecurity is the only such factor that is directly related to the pharmacokinetics of some antiretroviral medications. Achieving optimal treatment outcomes for HIV infection will require routine assessment of access to food when determining patient-tailored ART regimens. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40121-015-0057-y) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4363219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-43632192015-03-24 Medication Adherence and Health Outcomes of People Living with HIV Who Are Food Insecure and Prescribed Antiretrovirals That Should Be Taken with Food Kalichman, Seth C. Washington, Christopher Grebler, Tamar Hoyt, Ginger Welles, Brandi Kegler, Christopher Kalichman, Moira O. Cherry, Chauncey Infect Dis Ther Original Research INTRODUCTION: Food insecurity is a well-established predictor of poor health outcomes. Antiretroviral therapies (ARTs) that should be taken with food to increase bioavailability may further challenge food insecure patients. This study examined factors associated with antiretroviral adherence and HIV viral suppression among people living with HIV who are food insecure and prescribed medications that require food. METHODS: A community sample of 313 men and 105 women who experienced food insecurity in the previous month and were currently taking ART completed computerized interviews, urine screening for drug use, prospective biweekly unannounced pill count adherence assessments, and obtained their HIV viral load and CD4 cell counts from medical records. RESULTS: Individuals taking ART regimens that should be taken with food were significantly more likely to be unemployed, were living longer with an HIV diagnosis, had lower CD4 cell counts, poorer HIV suppression, and endorsed more beliefs that taking medications was necessary for their health. Multivariable regression models controlling for potential confounding factors showed that receiving ART that requires food was significantly related to poorer ART adherence and unsuppressed HIV in this food insecure sample. CONCLUSION: People living with HIV who are food insecure likely experience multiple facets of poverty that challenge their medication adherence, but food insecurity is the only such factor that is directly related to the pharmacokinetics of some antiretroviral medications. Achieving optimal treatment outcomes for HIV infection will require routine assessment of access to food when determining patient-tailored ART regimens. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40121-015-0057-y) contains supplementary material, which is available to authorized users. Springer Healthcare 2015-01-23 2015-03 /pmc/articles/PMC4363219/ /pubmed/25613643 http://dx.doi.org/10.1007/s40121-015-0057-y Text en © The Author(s) 2015 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Research Kalichman, Seth C. Washington, Christopher Grebler, Tamar Hoyt, Ginger Welles, Brandi Kegler, Christopher Kalichman, Moira O. Cherry, Chauncey Medication Adherence and Health Outcomes of People Living with HIV Who Are Food Insecure and Prescribed Antiretrovirals That Should Be Taken with Food |
title | Medication Adherence and Health Outcomes of People Living with HIV Who Are Food Insecure and Prescribed Antiretrovirals That Should Be Taken with Food |
title_full | Medication Adherence and Health Outcomes of People Living with HIV Who Are Food Insecure and Prescribed Antiretrovirals That Should Be Taken with Food |
title_fullStr | Medication Adherence and Health Outcomes of People Living with HIV Who Are Food Insecure and Prescribed Antiretrovirals That Should Be Taken with Food |
title_full_unstemmed | Medication Adherence and Health Outcomes of People Living with HIV Who Are Food Insecure and Prescribed Antiretrovirals That Should Be Taken with Food |
title_short | Medication Adherence and Health Outcomes of People Living with HIV Who Are Food Insecure and Prescribed Antiretrovirals That Should Be Taken with Food |
title_sort | medication adherence and health outcomes of people living with hiv who are food insecure and prescribed antiretrovirals that should be taken with food |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363219/ https://www.ncbi.nlm.nih.gov/pubmed/25613643 http://dx.doi.org/10.1007/s40121-015-0057-y |
work_keys_str_mv | AT kalichmansethc medicationadherenceandhealthoutcomesofpeoplelivingwithhivwhoarefoodinsecureandprescribedantiretroviralsthatshouldbetakenwithfood AT washingtonchristopher medicationadherenceandhealthoutcomesofpeoplelivingwithhivwhoarefoodinsecureandprescribedantiretroviralsthatshouldbetakenwithfood AT greblertamar medicationadherenceandhealthoutcomesofpeoplelivingwithhivwhoarefoodinsecureandprescribedantiretroviralsthatshouldbetakenwithfood AT hoytginger medicationadherenceandhealthoutcomesofpeoplelivingwithhivwhoarefoodinsecureandprescribedantiretroviralsthatshouldbetakenwithfood AT wellesbrandi medicationadherenceandhealthoutcomesofpeoplelivingwithhivwhoarefoodinsecureandprescribedantiretroviralsthatshouldbetakenwithfood AT keglerchristopher medicationadherenceandhealthoutcomesofpeoplelivingwithhivwhoarefoodinsecureandprescribedantiretroviralsthatshouldbetakenwithfood AT kalichmanmoirao medicationadherenceandhealthoutcomesofpeoplelivingwithhivwhoarefoodinsecureandprescribedantiretroviralsthatshouldbetakenwithfood AT cherrychauncey medicationadherenceandhealthoutcomesofpeoplelivingwithhivwhoarefoodinsecureandprescribedantiretroviralsthatshouldbetakenwithfood |