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Aberrant connexin26 hemichannels underlying keratitis-ichthyosis-deafness syndrome are potently inhibited by mefloquine

Keratitis-ichthyosis-deafness (KID) syndrome is an ectodermal dysplasia caused by dominant mutations of connexin26 (Cx26). Loss of Cx26 function causes non-syndromic sensorineural deafness, without consequence in the epidermis. Functional analyses have revealed that a majority of KID-causing mutatio...

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Detalles Bibliográficos
Autores principales:	Levit, Noah A., Sellitto, Caterina, Wang, Hong-Zhan, Li, Leping, Srinivas, Miduturu, Brink, Peter R., White, Thomas W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363291/ https://www.ncbi.nlm.nih.gov/pubmed/25229253 http://dx.doi.org/10.1038/jid.2014.408

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