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Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse
Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is currently no available testing paradigm utilizing touch-screen systems that can assess working me...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Brain and Neural Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363337/ https://www.ncbi.nlm.nih.gov/pubmed/25792872 http://dx.doi.org/10.5607/en.2015.24.1.84 |
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author | Kwak, Chuljung Lim, Chae-Seok Kaang, Bong-Kiun |
author_facet | Kwak, Chuljung Lim, Chae-Seok Kaang, Bong-Kiun |
author_sort | Kwak, Chuljung |
collection | PubMed |
description | Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is currently no available testing paradigm utilizing touch-screen systems that can assess working memory in the mouse. In this study, we developed a touch-screen testing paradigm in which mice were trained to choose a location that is matched to a sample location after a time delay. Consistent with previous studies, this study showed that mice could not only learn the rule in the delayed matched to position (DMTP), but also could retain a transitory memory of the sample position during delay. This indicates that a touch-screen system can provide a DMTP testing platform to assess working memory in the mouse. |
format | Online Article Text |
id | pubmed-4363337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Society for Brain and Neural Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43633372015-03-19 Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse Kwak, Chuljung Lim, Chae-Seok Kaang, Bong-Kiun Exp Neurobiol Original Article Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is currently no available testing paradigm utilizing touch-screen systems that can assess working memory in the mouse. In this study, we developed a touch-screen testing paradigm in which mice were trained to choose a location that is matched to a sample location after a time delay. Consistent with previous studies, this study showed that mice could not only learn the rule in the delayed matched to position (DMTP), but also could retain a transitory memory of the sample position during delay. This indicates that a touch-screen system can provide a DMTP testing platform to assess working memory in the mouse. The Korean Society for Brain and Neural Science 2015-03 2014-12-17 /pmc/articles/PMC4363337/ /pubmed/25792872 http://dx.doi.org/10.5607/en.2015.24.1.84 Text en Copyright © Experimental Neurobiology 2015. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kwak, Chuljung Lim, Chae-Seok Kaang, Bong-Kiun Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse |
title | Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse |
title_full | Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse |
title_fullStr | Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse |
title_full_unstemmed | Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse |
title_short | Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse |
title_sort | development of a touch-screen-based paradigm for assessing working memory in the mouse |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363337/ https://www.ncbi.nlm.nih.gov/pubmed/25792872 http://dx.doi.org/10.5607/en.2015.24.1.84 |
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