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Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse

Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is currently no available testing paradigm utilizing touch-screen systems that can assess working me...

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Autores principales: Kwak, Chuljung, Lim, Chae-Seok, Kaang, Bong-Kiun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363337/
https://www.ncbi.nlm.nih.gov/pubmed/25792872
http://dx.doi.org/10.5607/en.2015.24.1.84
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author Kwak, Chuljung
Lim, Chae-Seok
Kaang, Bong-Kiun
author_facet Kwak, Chuljung
Lim, Chae-Seok
Kaang, Bong-Kiun
author_sort Kwak, Chuljung
collection PubMed
description Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is currently no available testing paradigm utilizing touch-screen systems that can assess working memory in the mouse. In this study, we developed a touch-screen testing paradigm in which mice were trained to choose a location that is matched to a sample location after a time delay. Consistent with previous studies, this study showed that mice could not only learn the rule in the delayed matched to position (DMTP), but also could retain a transitory memory of the sample position during delay. This indicates that a touch-screen system can provide a DMTP testing platform to assess working memory in the mouse.
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spelling pubmed-43633372015-03-19 Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse Kwak, Chuljung Lim, Chae-Seok Kaang, Bong-Kiun Exp Neurobiol Original Article Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is currently no available testing paradigm utilizing touch-screen systems that can assess working memory in the mouse. In this study, we developed a touch-screen testing paradigm in which mice were trained to choose a location that is matched to a sample location after a time delay. Consistent with previous studies, this study showed that mice could not only learn the rule in the delayed matched to position (DMTP), but also could retain a transitory memory of the sample position during delay. This indicates that a touch-screen system can provide a DMTP testing platform to assess working memory in the mouse. The Korean Society for Brain and Neural Science 2015-03 2014-12-17 /pmc/articles/PMC4363337/ /pubmed/25792872 http://dx.doi.org/10.5607/en.2015.24.1.84 Text en Copyright © Experimental Neurobiology 2015. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kwak, Chuljung
Lim, Chae-Seok
Kaang, Bong-Kiun
Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse
title Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse
title_full Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse
title_fullStr Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse
title_full_unstemmed Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse
title_short Development of a Touch-Screen-Based Paradigm for Assessing Working Memory in the Mouse
title_sort development of a touch-screen-based paradigm for assessing working memory in the mouse
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363337/
https://www.ncbi.nlm.nih.gov/pubmed/25792872
http://dx.doi.org/10.5607/en.2015.24.1.84
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