Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations

Human PRS1, which is indispensable for the biosynthesis of nucleotides, deoxynucleotides and their derivatives, is associated directly with multiple human diseases because of single base mutation. However, a molecular understanding of the effect of these mutations is hampered by the lack of understa...

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Detalles Bibliográficos
Autores principales: Chen, Peng, Liu, Zheng, Wang, Xuejuan, Peng, Junhui, Sun, Qianqian, Li, Jianzhong, Wang, Mingxing, Niu, Liwen, Zhang, Zhiyong, Cai, Gang, Teng, Maikun, Li, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363470/
https://www.ncbi.nlm.nih.gov/pubmed/25781187
http://dx.doi.org/10.1371/journal.pone.0120304

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