A mutant BRAF V600E-specific immunohistochemical assay: correlation with molecular mutation status and clinical outcome in colorectal cancer

The B-type Raf kinase (BRAF) V600E mutation is a well-established biomarker for poor prognosis in metastatic colorectal cancer (mCRC) and is a highly attractive drug target. A barrier to the development of new therapies targeting BRAF V600E in mCRC is the low prevalence of mutations (approximately 1...

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Detalles Bibliográficos
Autores principales: Day, Fiona, Muranyi, Andrea, Singh, Shalini, Shanmugam, Kandavel, Williams, David, Byrne, David, Pham, Kym, Palmieri, Michelle, Tie, Jeanne, Grogan, Thomas, Gibbs, Peter, Sieber, Oliver, Waring, Paul, Desai, Jayesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363480/
https://www.ncbi.nlm.nih.gov/pubmed/24859797
http://dx.doi.org/10.1007/s11523-014-0319-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363480/
https://www.ncbi.nlm.nih.gov/pubmed/24859797
http://dx.doi.org/10.1007/s11523-014-0319-8

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