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Antioxidant Strategies in the Management of Diabetic Neuropathy

Chronic hyperglycaemia (an abnormally high glucose concentration in the blood) resulting from defects in insulin secretion/action, or both, is the major hallmark of diabetes in which it is known to be involved in the progression of the condition to different complications that include diabetic neuro...

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Autores principales: Oyenihi, Ayodeji Babatunde, Ayeleso, Ademola Olabode, Mukwevho, Emmanuel, Masola, Bubuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363503/
https://www.ncbi.nlm.nih.gov/pubmed/25821809
http://dx.doi.org/10.1155/2015/515042
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author Oyenihi, Ayodeji Babatunde
Ayeleso, Ademola Olabode
Mukwevho, Emmanuel
Masola, Bubuya
author_facet Oyenihi, Ayodeji Babatunde
Ayeleso, Ademola Olabode
Mukwevho, Emmanuel
Masola, Bubuya
author_sort Oyenihi, Ayodeji Babatunde
collection PubMed
description Chronic hyperglycaemia (an abnormally high glucose concentration in the blood) resulting from defects in insulin secretion/action, or both, is the major hallmark of diabetes in which it is known to be involved in the progression of the condition to different complications that include diabetic neuropathy. Diabetic neuropathy (diabetes-induced nerve damage) is the most common diabetic complication and can be devastating because it can lead to disability. There is an increasing body of evidence associating diabetic neuropathy with oxidative stress. Oxidative stress results from the production of oxygen free radicals in the body in excess of its ability to eliminate them by antioxidant activity. Antioxidants have different mechanisms and sites of actions by which they exert their biochemical effects and ameliorate nerve dysfunction in diabetes by acting directly against oxidative damage. This review will examine different strategies for managing diabetic neuropathy which rely on exogenous antioxidants.
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spelling pubmed-43635032015-03-29 Antioxidant Strategies in the Management of Diabetic Neuropathy Oyenihi, Ayodeji Babatunde Ayeleso, Ademola Olabode Mukwevho, Emmanuel Masola, Bubuya Biomed Res Int Review Article Chronic hyperglycaemia (an abnormally high glucose concentration in the blood) resulting from defects in insulin secretion/action, or both, is the major hallmark of diabetes in which it is known to be involved in the progression of the condition to different complications that include diabetic neuropathy. Diabetic neuropathy (diabetes-induced nerve damage) is the most common diabetic complication and can be devastating because it can lead to disability. There is an increasing body of evidence associating diabetic neuropathy with oxidative stress. Oxidative stress results from the production of oxygen free radicals in the body in excess of its ability to eliminate them by antioxidant activity. Antioxidants have different mechanisms and sites of actions by which they exert their biochemical effects and ameliorate nerve dysfunction in diabetes by acting directly against oxidative damage. This review will examine different strategies for managing diabetic neuropathy which rely on exogenous antioxidants. Hindawi Publishing Corporation 2015 2015-03-02 /pmc/articles/PMC4363503/ /pubmed/25821809 http://dx.doi.org/10.1155/2015/515042 Text en Copyright © 2015 Ayodeji Babatunde Oyenihi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Oyenihi, Ayodeji Babatunde
Ayeleso, Ademola Olabode
Mukwevho, Emmanuel
Masola, Bubuya
Antioxidant Strategies in the Management of Diabetic Neuropathy
title Antioxidant Strategies in the Management of Diabetic Neuropathy
title_full Antioxidant Strategies in the Management of Diabetic Neuropathy
title_fullStr Antioxidant Strategies in the Management of Diabetic Neuropathy
title_full_unstemmed Antioxidant Strategies in the Management of Diabetic Neuropathy
title_short Antioxidant Strategies in the Management of Diabetic Neuropathy
title_sort antioxidant strategies in the management of diabetic neuropathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363503/
https://www.ncbi.nlm.nih.gov/pubmed/25821809
http://dx.doi.org/10.1155/2015/515042
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