Identification and Characterization of PERK Activators by Phenotypic Screening and Their Effects on NRF2 Activation

Endoplasmic reticulum stress plays a critical role to restore the homeostasis of protein production in eukaryotic cells. This vital process is hence involved in many types of diseases including COPD. PERK, one branch in the ER stress signaling pathways, has been reported to activate NRF2 signaling p...

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Detalles Bibliográficos
Autores principales: Xie, Wensheng, Pariollaud, Marie, Wixted, William E., Chitnis, Nilesh, Fornwald, James, Truong, Maggie, Pao, Christina, Liu, Yan, Ames, Robert S., Callahan, James, Solari, Roberto, Sanchez, Yolanda, Diehl, Alan, Li, Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363567/
https://www.ncbi.nlm.nih.gov/pubmed/25780921
http://dx.doi.org/10.1371/journal.pone.0119738

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