Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action

High mobility group box 1 (HMGB1) is an evolutionarily conserved protein and is constitutively expressed in virtually all types of cells. In response to microbial infections, HMGB1 is secreted from activated immune cells to orchestrate rigorous inflammatory responses. Here we review the distinct mec...

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Detalles Bibliográficos
Autores principales: Wu, Andrew H., He, Li, Long, Wei, Zhou, Qiuping, Zhu, Shu, Wang, Ping, Fan, Saijun, Wang, Haichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363608/
https://www.ncbi.nlm.nih.gov/pubmed/25821489
http://dx.doi.org/10.1155/2015/456305
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author Wu, Andrew H.
He, Li
Long, Wei
Zhou, Qiuping
Zhu, Shu
Wang, Ping
Fan, Saijun
Wang, Haichao
author_facet Wu, Andrew H.
He, Li
Long, Wei
Zhou, Qiuping
Zhu, Shu
Wang, Ping
Fan, Saijun
Wang, Haichao
author_sort Wu, Andrew H.
collection PubMed
description High mobility group box 1 (HMGB1) is an evolutionarily conserved protein and is constitutively expressed in virtually all types of cells. In response to microbial infections, HMGB1 is secreted from activated immune cells to orchestrate rigorous inflammatory responses. Here we review the distinct mechanisms by which several herbal components inhibit HMGB1 action or secretion, such as by modulating inflammasome activation, autophagic degradation, or endocytic uptake. In light of the reciprocal interactions between these cellular processes, it is possible to develop more effective combinational herbal therapies for the clinical management of inflammatory diseases.
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spelling pubmed-43636082015-03-29 Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action Wu, Andrew H. He, Li Long, Wei Zhou, Qiuping Zhu, Shu Wang, Ping Fan, Saijun Wang, Haichao Evid Based Complement Alternat Med Review Article High mobility group box 1 (HMGB1) is an evolutionarily conserved protein and is constitutively expressed in virtually all types of cells. In response to microbial infections, HMGB1 is secreted from activated immune cells to orchestrate rigorous inflammatory responses. Here we review the distinct mechanisms by which several herbal components inhibit HMGB1 action or secretion, such as by modulating inflammasome activation, autophagic degradation, or endocytic uptake. In light of the reciprocal interactions between these cellular processes, it is possible to develop more effective combinational herbal therapies for the clinical management of inflammatory diseases. Hindawi Publishing Corporation 2015 2015-03-02 /pmc/articles/PMC4363608/ /pubmed/25821489 http://dx.doi.org/10.1155/2015/456305 Text en Copyright © 2015 Andrew H. Wu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wu, Andrew H.
He, Li
Long, Wei
Zhou, Qiuping
Zhu, Shu
Wang, Ping
Fan, Saijun
Wang, Haichao
Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action
title Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action
title_full Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action
title_fullStr Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action
title_full_unstemmed Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action
title_short Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action
title_sort novel mechanisms of herbal therapies for inhibiting hmgb1 secretion or action
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363608/
https://www.ncbi.nlm.nih.gov/pubmed/25821489
http://dx.doi.org/10.1155/2015/456305
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