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Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis
Sepsis, the leading cause of mortality in intensive care unit, is characterized by hyperinflammatory response in the early stage and followed by a period of immunosuppression. This immune disorder is believed to be the potent factor that is tightly associated with high mortality in sepsis. Dendritic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363672/ https://www.ncbi.nlm.nih.gov/pubmed/25821827 http://dx.doi.org/10.1155/2015/903720 |
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author | Fan, Xia Liu, Zheng Jin, He Yan, Jun Liang, Hua-ping |
author_facet | Fan, Xia Liu, Zheng Jin, He Yan, Jun Liang, Hua-ping |
author_sort | Fan, Xia |
collection | PubMed |
description | Sepsis, the leading cause of mortality in intensive care unit, is characterized by hyperinflammatory response in the early stage and followed by a period of immunosuppression. This immune disorder is believed to be the potent factor that is tightly associated with high mortality in sepsis. Dendritic cells (DCs) serve as professional antigen-presenting cells that play a vital role in immune response by activating T lymphocytes. During the progression of sepsis, DCs have been reported to take part in the aberrant immune response and be necessary for survival. Therefore, a better understanding of the DCs pathology will be undoubtedly beneficial for resolving the problems occurring in sepsis. This review discusses effects of sepsis on DCs number and function, including surface molecules expression, cytokines secretion, and T cell activation, and the underlying mechanism as well as some potential therapeutic strategies. |
format | Online Article Text |
id | pubmed-4363672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43636722015-03-29 Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis Fan, Xia Liu, Zheng Jin, He Yan, Jun Liang, Hua-ping Biomed Res Int Review Article Sepsis, the leading cause of mortality in intensive care unit, is characterized by hyperinflammatory response in the early stage and followed by a period of immunosuppression. This immune disorder is believed to be the potent factor that is tightly associated with high mortality in sepsis. Dendritic cells (DCs) serve as professional antigen-presenting cells that play a vital role in immune response by activating T lymphocytes. During the progression of sepsis, DCs have been reported to take part in the aberrant immune response and be necessary for survival. Therefore, a better understanding of the DCs pathology will be undoubtedly beneficial for resolving the problems occurring in sepsis. This review discusses effects of sepsis on DCs number and function, including surface molecules expression, cytokines secretion, and T cell activation, and the underlying mechanism as well as some potential therapeutic strategies. Hindawi Publishing Corporation 2015 2015-03-02 /pmc/articles/PMC4363672/ /pubmed/25821827 http://dx.doi.org/10.1155/2015/903720 Text en Copyright © 2015 Xia Fan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fan, Xia Liu, Zheng Jin, He Yan, Jun Liang, Hua-ping Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis |
title | Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis |
title_full | Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis |
title_fullStr | Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis |
title_full_unstemmed | Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis |
title_short | Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis |
title_sort | alterations of dendritic cells in sepsis: featured role in immunoparalysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363672/ https://www.ncbi.nlm.nih.gov/pubmed/25821827 http://dx.doi.org/10.1155/2015/903720 |
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