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Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training
PURPOSE: Irisin is a recently identified exercise-induced hormone that increases energy expenditure, at least in rodents. The main purpose of this study was to test the hypothesis that Irisin increases acutely in blood after singular sessions of intense endurance exercise (END) and heavy strength tr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363689/ https://www.ncbi.nlm.nih.gov/pubmed/25781950 http://dx.doi.org/10.1371/journal.pone.0121367 |
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author | Nygaard, Håvard Slettaløkken, Gunnar Vegge, Geir Hollan, Ivana Whist, Jon Elling Strand, Tor Rønnestad, Bent R. Ellefsen, Stian |
author_facet | Nygaard, Håvard Slettaløkken, Gunnar Vegge, Geir Hollan, Ivana Whist, Jon Elling Strand, Tor Rønnestad, Bent R. Ellefsen, Stian |
author_sort | Nygaard, Håvard |
collection | PubMed |
description | PURPOSE: Irisin is a recently identified exercise-induced hormone that increases energy expenditure, at least in rodents. The main purpose of this study was to test the hypothesis that Irisin increases acutely in blood after singular sessions of intense endurance exercise (END) and heavy strength training (STR). Secondary, we wanted to explore the relationship between body composition and exercise-induced effects on irisin, and the effect of END and STR on muscular expression of the irisin gene FNDC5. METHODS: Nine moderately trained healthy subjects performed three test days using a randomized and standardized crossover design: one day with 60 minutes of END, one day with 60 minutes of STR, and one day without exercise (CON). Venous blood was sampled over a period of 24h on the exercise days. RESULTS: Both END and STR led to transient increases in irisin concentrations in blood, peaking immediately after END and one hour after STR, before gradually returning to baseline. Irisin responses to STR, but not END, showed a consistently strong negative correlation with proportions of lean body mass. Neither END nor STR affected expression of FNDC5, measured 4h after training sessions, though both protocols led to pronounced increases in PGC-1α expression, which is involved in transcriptional control of FNDC5. CONCLUSION: The results strongly suggest that single sessions of intense endurance exercise and heavy strength training lead to transient increases in irisin concentrations in blood. This was not accompanied by increased FNDC5 expression, measured 4h post-exercise. The results suggest that irisin responses to resistance exercise are higher in individuals with lower proportions of lean body mass. |
format | Online Article Text |
id | pubmed-4363689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43636892015-03-23 Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training Nygaard, Håvard Slettaløkken, Gunnar Vegge, Geir Hollan, Ivana Whist, Jon Elling Strand, Tor Rønnestad, Bent R. Ellefsen, Stian PLoS One Research Article PURPOSE: Irisin is a recently identified exercise-induced hormone that increases energy expenditure, at least in rodents. The main purpose of this study was to test the hypothesis that Irisin increases acutely in blood after singular sessions of intense endurance exercise (END) and heavy strength training (STR). Secondary, we wanted to explore the relationship between body composition and exercise-induced effects on irisin, and the effect of END and STR on muscular expression of the irisin gene FNDC5. METHODS: Nine moderately trained healthy subjects performed three test days using a randomized and standardized crossover design: one day with 60 minutes of END, one day with 60 minutes of STR, and one day without exercise (CON). Venous blood was sampled over a period of 24h on the exercise days. RESULTS: Both END and STR led to transient increases in irisin concentrations in blood, peaking immediately after END and one hour after STR, before gradually returning to baseline. Irisin responses to STR, but not END, showed a consistently strong negative correlation with proportions of lean body mass. Neither END nor STR affected expression of FNDC5, measured 4h after training sessions, though both protocols led to pronounced increases in PGC-1α expression, which is involved in transcriptional control of FNDC5. CONCLUSION: The results strongly suggest that single sessions of intense endurance exercise and heavy strength training lead to transient increases in irisin concentrations in blood. This was not accompanied by increased FNDC5 expression, measured 4h post-exercise. The results suggest that irisin responses to resistance exercise are higher in individuals with lower proportions of lean body mass. Public Library of Science 2015-03-17 /pmc/articles/PMC4363689/ /pubmed/25781950 http://dx.doi.org/10.1371/journal.pone.0121367 Text en © 2015 Nygaard et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Nygaard, Håvard Slettaløkken, Gunnar Vegge, Geir Hollan, Ivana Whist, Jon Elling Strand, Tor Rønnestad, Bent R. Ellefsen, Stian Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training |
title | Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training |
title_full | Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training |
title_fullStr | Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training |
title_full_unstemmed | Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training |
title_short | Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training |
title_sort | irisin in blood increases transiently after single sessions of intense endurance exercise and heavy strength training |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363689/ https://www.ncbi.nlm.nih.gov/pubmed/25781950 http://dx.doi.org/10.1371/journal.pone.0121367 |
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