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Cyclooxygenase-2 Suppresses the Anabolic Response to PTH Infusion in Mice

We previously reported that the ability of continuously elevated PTH to stimulate osteoblastic differentiation in bone marrow stromal cell cultures was abrogated by an osteoclastic factor secreted in response to cyclooxygenase-2 (Cox2)-produced prostaglandin E(2). We now examine the impact of Cox2 (...

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Detalles Bibliográficos
Autores principales: Choudhary, Shilpa, Canalis, Ernesto, Estus, Thomas, Adams, Douglas, Pilbeam, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363701/
https://www.ncbi.nlm.nih.gov/pubmed/25781979
http://dx.doi.org/10.1371/journal.pone.0120164