Cargando…

Brca2 Deficiency Leads to T Cell Loss and Immune Dysfunction

Germline mutations in the breast cancer type 2 susceptibility gene (BRCA2) are linked to familial breast cancer and the progressive bone marrow failure syndrome Fanconi anaemia. Established Brca2 mouse knockout models show embryonic lethality, but those with a truncating mutation at the C-terminus s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeong, Jun-hyeon, Jo, Areum, Park, Pilgu, Lee, Hyunsook, Lee, Hae-Ock
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363725/ https://www.ncbi.nlm.nih.gov/pubmed/25666348 http://dx.doi.org/10.14348/molcells.2015.2302

Ejemplares similares

Prescreening of tumor samples for tumor-centric transcriptome analyses of lung adenocarcinoma
por: Kim, Nayoung, et al.
Publicado: (2022)

Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis
por: Lee, Junyeop, et al.
Publicado: (2022)

Paradoxical delay of senescence upon depletion of BRCA2 in telomerase‐deficient worms
por: Kwon, Mi‐Sun, et al.
Publicado: (2016)

Perspectives on single-nucleus RNA sequencing in different cell types and tissues
por: Kim, Nayoung, et al.
Publicado: (2023)

PAR2 Deficiency Induces Mitochondrial ROS Generation and Dysfunctions, Leading to the Inhibition of Adipocyte Differentiation
por: Park, Yeo Jin, et al.
Publicado: (2021)

Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation
por: Park, Inai, et al.
Publicado: (2013)

Uptake of Family-Specific Mutation Genetic Testing Among Relatives of Patients with Ovarian Cancer with BRCA1 or BRCA2 Mutation
por: Jeong, Go Woon, et al.
Publicado: (2021)

Biallelic BRCA Loss and Homologous Recombination Deficiency in Nonbreast/Ovarian Tumors in Germline BRCA1/2 Carriers
por: Wineland, Dylane, et al.
Publicado: (2023)

Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation
por: Khang, Rin, et al.
Publicado: (2021)

How Chromosome Mis-Segregation Leads to Cancer: Lessons from BubR1 Mouse Models
por: Lee, Hyunsook
Publicado: (2014)

TMBIM6 deficiency leads to bone loss by accelerating osteoclastogenesis
por: Yi, Sun-Ju, et al.
Publicado: (2023)

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
por: Bouwman, Peter, et al.
Publicado: (2010)

BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers
por: Maxwell, Kara N., et al.
Publicado: (2017)

LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain
por: Park, Jun Sung, et al.
Publicado: (2022)

Partial Hepatectomy in Acetylation-Deficient BubR1 Mice Corroborates that Chromosome Missegregation Initiates Tumorigenesis
por: Lee, Yoo-Kyung, et al.
Publicado: (2014)

Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer
por: Eum, Hye Hyeon, et al.
Publicado: (2020)

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
por: Bajrami, Ilirjana, et al.
Publicado: (2021)

Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss
por: So, Hyun-Kyung, et al.
Publicado: (2023)

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds
por: Zimmer, Jutta, et al.
Publicado: (2016)

Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient
por: Lee, Hye Won, et al.
Publicado: (2020)

Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer
por: Kalachand, Roshni D., et al.
Publicado: (2020)

Characteristics of BRCA1/2 mutations carriers including large genomic rearrangements in high risk breast cancer patients
por: Park, Boyoung, et al.
Publicado: (2017)

BRCA1 deficiency in mature CD8(+) T lymphocytes impairs antitumor immunity
por: Wu, Bogang, et al.
Publicado: (2023)

Dysfunction of macrophages leads to diabetic bone regeneration deficiency
por: Shen, Yufeng, et al.
Publicado: (2022)

Estimating utility weights and quality-adjusted life year loss for colorectal cancer-related health states in Korea
por: Lee, Jin Yong, et al.
Publicado: (2017)

Characterization of BRCA Deficiency in Ovarian Cancer
por: Barbero, Giovanna, et al.
Publicado: (2023)

Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection
por: Kang, Hojin, et al.
Publicado: (2017)

Copine7 deficiency leads to hepatic fat accumulation via mitochondrial dysfunction
por: Hwang, Geumbit, et al.
Publicado: (2023)

Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors
por: Huang, Fei, et al.
Publicado: (2016)

Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers
por: Setton, Jeremy, et al.
Publicado: (2023)

Do microdeletions lead to immune deficiency?
por: KARAMAN, SAIT, et al.
Publicado: (2020)

Mitochondrial Dysfunction in Podocytes Caused by CRIF1 Deficiency Leads to Progressive Albuminuria and Glomerular Sclerosis in Mice
por: Na, Ki Ryang, et al.
Publicado: (2021)

Oxidative stress-mediated TXNIP loss causes RPE dysfunction
por: Ji Cho, Min, et al.
Publicado: (2019)

BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis
por: Li, Qianyan, et al.
Publicado: (2021)

Performance evaluation of an amplicon‐based next‐generation sequencing panel for BRCA1 and BRCA2 variant detection
por: Park, Kuenyoul, et al.
Publicado: (2020)

MMR-deficiency and BRCA2/EGFR/NTRK mutations
por: Gokare, Prashanth, et al.
Publicado: (2017)

PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors
por: Staniszewska, Anna D., et al.
Publicado: (2022)

Endoplasmic reticulum stress activates transglutaminase 2 leading to protein aggregation
por: LEE, JIN-HAENG, et al.
Publicado: (2014)

BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)
por: Chen, Qiang, et al.
Publicado: (2020)

Evaluation of BRCA1 and BRCA2 as Indicators of Response to Immune Checkpoint Inhibitors
por: Zhou, Zhijun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o1ae8v2566m9072r0hmkeviajl