Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization

Osteoarthritis (OA) is the most common joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer use...

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Autores principales: Imamura, Marta, Ezquerro, Fernando, Marcon Alfieri, Fábio, Vilas Boas, Lucy, Tozetto-Mendoza, Tania Regina, Chen, Janini, Özçakar, Levent, Arendt-Nielsen, Lars, Rizzo Battistella, Linamara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363921/
https://www.ncbi.nlm.nih.gov/pubmed/25821631
http://dx.doi.org/10.1155/2015/329792
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author Imamura, Marta
Ezquerro, Fernando
Marcon Alfieri, Fábio
Vilas Boas, Lucy
Tozetto-Mendoza, Tania Regina
Chen, Janini
Özçakar, Levent
Arendt-Nielsen, Lars
Rizzo Battistella, Linamara
author_facet Imamura, Marta
Ezquerro, Fernando
Marcon Alfieri, Fábio
Vilas Boas, Lucy
Tozetto-Mendoza, Tania Regina
Chen, Janini
Özçakar, Levent
Arendt-Nielsen, Lars
Rizzo Battistella, Linamara
author_sort Imamura, Marta
collection PubMed
description Osteoarthritis (OA) is the most common joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis. Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients' functional capacity and pressure pain threshold (PPT) values.
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spelling pubmed-43639212015-03-29 Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization Imamura, Marta Ezquerro, Fernando Marcon Alfieri, Fábio Vilas Boas, Lucy Tozetto-Mendoza, Tania Regina Chen, Janini Özçakar, Levent Arendt-Nielsen, Lars Rizzo Battistella, Linamara Int J Inflam Research Article Osteoarthritis (OA) is the most common joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis. Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients' functional capacity and pressure pain threshold (PPT) values. Hindawi Publishing Corporation 2015 2015-03-02 /pmc/articles/PMC4363921/ /pubmed/25821631 http://dx.doi.org/10.1155/2015/329792 Text en Copyright © 2015 Marta Imamura et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Imamura, Marta
Ezquerro, Fernando
Marcon Alfieri, Fábio
Vilas Boas, Lucy
Tozetto-Mendoza, Tania Regina
Chen, Janini
Özçakar, Levent
Arendt-Nielsen, Lars
Rizzo Battistella, Linamara
Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization
title Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization
title_full Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization
title_fullStr Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization
title_full_unstemmed Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization
title_short Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization
title_sort serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363921/
https://www.ncbi.nlm.nih.gov/pubmed/25821631
http://dx.doi.org/10.1155/2015/329792
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