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Tinnitus: A Large VBM-EEG Correlational Study

A surprising fact in voxel-based morphometry (VBM) studies performed in tinnitus is that not one single region is replicated in studies of different centers. The question then rises whether this is related to the low sample size of these studies, the selection of non-representative patient subgroups...

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Autores principales: Vanneste, Sven, Van De Heyning, Paul, De Ridder, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364116/
https://www.ncbi.nlm.nih.gov/pubmed/25781934
http://dx.doi.org/10.1371/journal.pone.0115122
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author Vanneste, Sven
Van De Heyning, Paul
De Ridder, Dirk
author_facet Vanneste, Sven
Van De Heyning, Paul
De Ridder, Dirk
author_sort Vanneste, Sven
collection PubMed
description A surprising fact in voxel-based morphometry (VBM) studies performed in tinnitus is that not one single region is replicated in studies of different centers. The question then rises whether this is related to the low sample size of these studies, the selection of non-representative patient subgroups, or the absence of stratification according to clinical characteristics. Another possibility is that VBM is not a good tool to study functional pathologies such as tinnitus, in contrast to pathologies like Alzheimer’s disease where it is known the pathology is related to cell loss. In a large sample of 154 tinnitus patients VBM and QEEG (Quantitative Electroencephalography) was performed and evaluated by a regression analysis. Correlation analyses are performed between VBM and QEEG data. Uncorrected data demonstrated structural differences in grey matter in hippocampal and cerebellar areas related to tinnitus related distress and tinnitus duration. After control for multiple comparisons, only cerebellar VBM changes remain significantly altered. Electrophysiological differences are related to distress, tinnitus intensity, and tinnitus duration in the subgenual anterior cingulate cortex, dorsal anterior cingulate cortex, hippocampus, and parahippocampus, which confirms previous results. The absence of QEEG-VBM correlations suggest functional changes are not reflected by co-occurring structural changes in tinnitus, and the absence of VBM changes (except for the cerebellum) that survive correct statistical analysis in a large study population suggests that VBM might not be very sensitive for studying tinnitus.
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spelling pubmed-43641162015-03-23 Tinnitus: A Large VBM-EEG Correlational Study Vanneste, Sven Van De Heyning, Paul De Ridder, Dirk PLoS One Research Article A surprising fact in voxel-based morphometry (VBM) studies performed in tinnitus is that not one single region is replicated in studies of different centers. The question then rises whether this is related to the low sample size of these studies, the selection of non-representative patient subgroups, or the absence of stratification according to clinical characteristics. Another possibility is that VBM is not a good tool to study functional pathologies such as tinnitus, in contrast to pathologies like Alzheimer’s disease where it is known the pathology is related to cell loss. In a large sample of 154 tinnitus patients VBM and QEEG (Quantitative Electroencephalography) was performed and evaluated by a regression analysis. Correlation analyses are performed between VBM and QEEG data. Uncorrected data demonstrated structural differences in grey matter in hippocampal and cerebellar areas related to tinnitus related distress and tinnitus duration. After control for multiple comparisons, only cerebellar VBM changes remain significantly altered. Electrophysiological differences are related to distress, tinnitus intensity, and tinnitus duration in the subgenual anterior cingulate cortex, dorsal anterior cingulate cortex, hippocampus, and parahippocampus, which confirms previous results. The absence of QEEG-VBM correlations suggest functional changes are not reflected by co-occurring structural changes in tinnitus, and the absence of VBM changes (except for the cerebellum) that survive correct statistical analysis in a large study population suggests that VBM might not be very sensitive for studying tinnitus. Public Library of Science 2015-03-17 /pmc/articles/PMC4364116/ /pubmed/25781934 http://dx.doi.org/10.1371/journal.pone.0115122 Text en © 2015 Vanneste et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Vanneste, Sven
Van De Heyning, Paul
De Ridder, Dirk
Tinnitus: A Large VBM-EEG Correlational Study
title Tinnitus: A Large VBM-EEG Correlational Study
title_full Tinnitus: A Large VBM-EEG Correlational Study
title_fullStr Tinnitus: A Large VBM-EEG Correlational Study
title_full_unstemmed Tinnitus: A Large VBM-EEG Correlational Study
title_short Tinnitus: A Large VBM-EEG Correlational Study
title_sort tinnitus: a large vbm-eeg correlational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364116/
https://www.ncbi.nlm.nih.gov/pubmed/25781934
http://dx.doi.org/10.1371/journal.pone.0115122
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