Cargando…
Hydroxyapatite Whisker Reinforced 63s Glass Scaffolds for Bone Tissue Engineering
Bioactive glass (BG) is widely used for bone tissue engineering. However, poor mechanical properties are the major shortcomings. In the study, hydroxyapatite nanowhisker (HANw) was used as a reinforcement to improve the mechanical properties. 63s glass/HANw scaffolds were successfully fabricated by...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364126/ https://www.ncbi.nlm.nih.gov/pubmed/25821798 http://dx.doi.org/10.1155/2015/379294 |
_version_ | 1782362030414495744 |
---|---|
author | Shuai, Cijun Cao, Yiyuan Gao, Chengde Feng, Pei Xiao, Tao Peng, Shuping |
author_facet | Shuai, Cijun Cao, Yiyuan Gao, Chengde Feng, Pei Xiao, Tao Peng, Shuping |
author_sort | Shuai, Cijun |
collection | PubMed |
description | Bioactive glass (BG) is widely used for bone tissue engineering. However, poor mechanical properties are the major shortcomings. In the study, hydroxyapatite nanowhisker (HANw) was used as a reinforcement to improve the mechanical properties. 63s glass/HANw scaffolds were successfully fabricated by selective laser sintering (SLS). It was found that the optimal compressive strength and fracture toughness were achieved when 10 wt.% HANw was added. This led to 36% increase in compressive strength and 83% increase in fracture toughness, respectively, compared with pure 63s glass scaffolds. Different reinforcement mechanisms were analyzed based on the microstructure investigation. Whisker bridging and whisker pulling-out were efficient in absorbing crack propagating energy, resulting in the improvement of the mechanical properties. Moreover, bioactivity and biocompatibility of the scaffolds were evaluated in vitro. The results showed that composite scaffolds with 10 wt.% HANw exhibited good apatite-forming ability and cellular affinity. |
format | Online Article Text |
id | pubmed-4364126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43641262015-03-29 Hydroxyapatite Whisker Reinforced 63s Glass Scaffolds for Bone Tissue Engineering Shuai, Cijun Cao, Yiyuan Gao, Chengde Feng, Pei Xiao, Tao Peng, Shuping Biomed Res Int Research Article Bioactive glass (BG) is widely used for bone tissue engineering. However, poor mechanical properties are the major shortcomings. In the study, hydroxyapatite nanowhisker (HANw) was used as a reinforcement to improve the mechanical properties. 63s glass/HANw scaffolds were successfully fabricated by selective laser sintering (SLS). It was found that the optimal compressive strength and fracture toughness were achieved when 10 wt.% HANw was added. This led to 36% increase in compressive strength and 83% increase in fracture toughness, respectively, compared with pure 63s glass scaffolds. Different reinforcement mechanisms were analyzed based on the microstructure investigation. Whisker bridging and whisker pulling-out were efficient in absorbing crack propagating energy, resulting in the improvement of the mechanical properties. Moreover, bioactivity and biocompatibility of the scaffolds were evaluated in vitro. The results showed that composite scaffolds with 10 wt.% HANw exhibited good apatite-forming ability and cellular affinity. Hindawi Publishing Corporation 2015 2015-03-04 /pmc/articles/PMC4364126/ /pubmed/25821798 http://dx.doi.org/10.1155/2015/379294 Text en Copyright © 2015 Cijun Shuai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shuai, Cijun Cao, Yiyuan Gao, Chengde Feng, Pei Xiao, Tao Peng, Shuping Hydroxyapatite Whisker Reinforced 63s Glass Scaffolds for Bone Tissue Engineering |
title | Hydroxyapatite Whisker Reinforced 63s Glass Scaffolds for Bone Tissue Engineering |
title_full | Hydroxyapatite Whisker Reinforced 63s Glass Scaffolds for Bone Tissue Engineering |
title_fullStr | Hydroxyapatite Whisker Reinforced 63s Glass Scaffolds for Bone Tissue Engineering |
title_full_unstemmed | Hydroxyapatite Whisker Reinforced 63s Glass Scaffolds for Bone Tissue Engineering |
title_short | Hydroxyapatite Whisker Reinforced 63s Glass Scaffolds for Bone Tissue Engineering |
title_sort | hydroxyapatite whisker reinforced 63s glass scaffolds for bone tissue engineering |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364126/ https://www.ncbi.nlm.nih.gov/pubmed/25821798 http://dx.doi.org/10.1155/2015/379294 |
work_keys_str_mv | AT shuaicijun hydroxyapatitewhiskerreinforced63sglassscaffoldsforbonetissueengineering AT caoyiyuan hydroxyapatitewhiskerreinforced63sglassscaffoldsforbonetissueengineering AT gaochengde hydroxyapatitewhiskerreinforced63sglassscaffoldsforbonetissueengineering AT fengpei hydroxyapatitewhiskerreinforced63sglassscaffoldsforbonetissueengineering AT xiaotao hydroxyapatitewhiskerreinforced63sglassscaffoldsforbonetissueengineering AT pengshuping hydroxyapatitewhiskerreinforced63sglassscaffoldsforbonetissueengineering |