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Aberrant cerebellar connectivity in motor and association networks in schizophrenia

Schizophrenia is a devastating illness characterized by disturbances in multiple domains. The cerebellum is involved in both motor and non-motor functions, and the “cognitive dysmetria” and “dysmetria of thought” models propose that abnormalities of the cerebellum may contribute to schizophrenia sig...

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Autores principales: Shinn, Ann K., Baker, Justin T., Lewandowski, Kathryn E., Öngür, Dost, Cohen, Bruce M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364170/
https://www.ncbi.nlm.nih.gov/pubmed/25852520
http://dx.doi.org/10.3389/fnhum.2015.00134
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author Shinn, Ann K.
Baker, Justin T.
Lewandowski, Kathryn E.
Öngür, Dost
Cohen, Bruce M.
author_facet Shinn, Ann K.
Baker, Justin T.
Lewandowski, Kathryn E.
Öngür, Dost
Cohen, Bruce M.
author_sort Shinn, Ann K.
collection PubMed
description Schizophrenia is a devastating illness characterized by disturbances in multiple domains. The cerebellum is involved in both motor and non-motor functions, and the “cognitive dysmetria” and “dysmetria of thought” models propose that abnormalities of the cerebellum may contribute to schizophrenia signs and symptoms. The cerebellum and cerebral cortex are reciprocally connected via a modular, closed-loop network architecture, but few schizophrenia neuroimaging studies have taken into account the topographical and functional heterogeneity of the cerebellum. In this study, using a previously defined 17-network cerebral cortical parcellation system as the basis for our functional connectivity seeds, we systematically investigated connectivity abnormalities within the cerebellum of 44 schizophrenia patients and 28 healthy control participants. We found selective alterations in cerebro-cerebellar functional connectivity. Specifically, schizophrenia patients showed decreased cerebro-cerebellar functional connectivity in higher level association networks (ventral attention, salience, control, and default mode networks) relative to healthy control participants. Schizophrenia patients also showed increased cerebro-cerebellar connectivity in somatomotor and default mode networks, with the latter showing no overlap with the regions found to be hypoconnected within the same default mode network. Finally, we found evidence to suggest that somatomotor and default mode networks may be inappropriately linked in schizophrenia. The relationship of these dysconnectivities to schizophrenia symptoms, such as neurological soft signs and altered sense of agency, is discussed. We conclude that the cerebellum ought to be considered for analysis in all future studies of network abnormalities in SZ, and further suggest the cerebellum as a potential target for further elucidation, and possibly treatment, of the underlying mechanisms and network abnormalities producing symptoms of schizophrenia.
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spelling pubmed-43641702015-04-07 Aberrant cerebellar connectivity in motor and association networks in schizophrenia Shinn, Ann K. Baker, Justin T. Lewandowski, Kathryn E. Öngür, Dost Cohen, Bruce M. Front Hum Neurosci Neuroscience Schizophrenia is a devastating illness characterized by disturbances in multiple domains. The cerebellum is involved in both motor and non-motor functions, and the “cognitive dysmetria” and “dysmetria of thought” models propose that abnormalities of the cerebellum may contribute to schizophrenia signs and symptoms. The cerebellum and cerebral cortex are reciprocally connected via a modular, closed-loop network architecture, but few schizophrenia neuroimaging studies have taken into account the topographical and functional heterogeneity of the cerebellum. In this study, using a previously defined 17-network cerebral cortical parcellation system as the basis for our functional connectivity seeds, we systematically investigated connectivity abnormalities within the cerebellum of 44 schizophrenia patients and 28 healthy control participants. We found selective alterations in cerebro-cerebellar functional connectivity. Specifically, schizophrenia patients showed decreased cerebro-cerebellar functional connectivity in higher level association networks (ventral attention, salience, control, and default mode networks) relative to healthy control participants. Schizophrenia patients also showed increased cerebro-cerebellar connectivity in somatomotor and default mode networks, with the latter showing no overlap with the regions found to be hypoconnected within the same default mode network. Finally, we found evidence to suggest that somatomotor and default mode networks may be inappropriately linked in schizophrenia. The relationship of these dysconnectivities to schizophrenia symptoms, such as neurological soft signs and altered sense of agency, is discussed. We conclude that the cerebellum ought to be considered for analysis in all future studies of network abnormalities in SZ, and further suggest the cerebellum as a potential target for further elucidation, and possibly treatment, of the underlying mechanisms and network abnormalities producing symptoms of schizophrenia. Frontiers Media S.A. 2015-03-18 /pmc/articles/PMC4364170/ /pubmed/25852520 http://dx.doi.org/10.3389/fnhum.2015.00134 Text en Copyright © 2015 Shinn, Baker, Lewandowski, Öngür and Cohen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Shinn, Ann K.
Baker, Justin T.
Lewandowski, Kathryn E.
Öngür, Dost
Cohen, Bruce M.
Aberrant cerebellar connectivity in motor and association networks in schizophrenia
title Aberrant cerebellar connectivity in motor and association networks in schizophrenia
title_full Aberrant cerebellar connectivity in motor and association networks in schizophrenia
title_fullStr Aberrant cerebellar connectivity in motor and association networks in schizophrenia
title_full_unstemmed Aberrant cerebellar connectivity in motor and association networks in schizophrenia
title_short Aberrant cerebellar connectivity in motor and association networks in schizophrenia
title_sort aberrant cerebellar connectivity in motor and association networks in schizophrenia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364170/
https://www.ncbi.nlm.nih.gov/pubmed/25852520
http://dx.doi.org/10.3389/fnhum.2015.00134
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