Robust and Sustained Effect of Ketamine Infusions Coadministered with Conventional Antidepressants in a Patient with Refractory Major Depression

Antidepressant treatments show low capacity to achieve full clinical remissions. Electroconvulsive therapy is an alternative treatment which has been shown to be more effective but it is not well tolerated and there are concerns regarding its safety. We present the case of a patient with resistant d...

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Autores principales: Montes, José Manuel, Luján, Elena, Pascual, Fernado, Beleña, Jose María, Perez-Santar, Jose Luis, Irastorza, Luis Javier, Saiz-Ruiz, Jerónimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364451/
https://www.ncbi.nlm.nih.gov/pubmed/25821622
http://dx.doi.org/10.1155/2015/815673
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author Montes, José Manuel
Luján, Elena
Pascual, Fernado
Beleña, Jose María
Perez-Santar, Jose Luis
Irastorza, Luis Javier
Saiz-Ruiz, Jerónimo
author_facet Montes, José Manuel
Luján, Elena
Pascual, Fernado
Beleña, Jose María
Perez-Santar, Jose Luis
Irastorza, Luis Javier
Saiz-Ruiz, Jerónimo
author_sort Montes, José Manuel
collection PubMed
description Antidepressant treatments show low capacity to achieve full clinical remissions. Electroconvulsive therapy is an alternative treatment which has been shown to be more effective but it is not well tolerated and there are concerns regarding its safety. We present the case of a patient with resistant depression and modest and transient response to ECT and who showed a robust and maintained response after six i.v. ketamine (0.5 mg/kg) infusions without withdrawing her antidepressant regimen. Ketamine was very well tolerated. This case illustrates the potential role of ketamine as a booster to standard antidepressants.
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spelling pubmed-43644512015-03-29 Robust and Sustained Effect of Ketamine Infusions Coadministered with Conventional Antidepressants in a Patient with Refractory Major Depression Montes, José Manuel Luján, Elena Pascual, Fernado Beleña, Jose María Perez-Santar, Jose Luis Irastorza, Luis Javier Saiz-Ruiz, Jerónimo Case Rep Psychiatry Case Report Antidepressant treatments show low capacity to achieve full clinical remissions. Electroconvulsive therapy is an alternative treatment which has been shown to be more effective but it is not well tolerated and there are concerns regarding its safety. We present the case of a patient with resistant depression and modest and transient response to ECT and who showed a robust and maintained response after six i.v. ketamine (0.5 mg/kg) infusions without withdrawing her antidepressant regimen. Ketamine was very well tolerated. This case illustrates the potential role of ketamine as a booster to standard antidepressants. Hindawi Publishing Corporation 2015 2015-03-04 /pmc/articles/PMC4364451/ /pubmed/25821622 http://dx.doi.org/10.1155/2015/815673 Text en Copyright © 2015 José Manuel Montes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Montes, José Manuel
Luján, Elena
Pascual, Fernado
Beleña, Jose María
Perez-Santar, Jose Luis
Irastorza, Luis Javier
Saiz-Ruiz, Jerónimo
Robust and Sustained Effect of Ketamine Infusions Coadministered with Conventional Antidepressants in a Patient with Refractory Major Depression
title Robust and Sustained Effect of Ketamine Infusions Coadministered with Conventional Antidepressants in a Patient with Refractory Major Depression
title_full Robust and Sustained Effect of Ketamine Infusions Coadministered with Conventional Antidepressants in a Patient with Refractory Major Depression
title_fullStr Robust and Sustained Effect of Ketamine Infusions Coadministered with Conventional Antidepressants in a Patient with Refractory Major Depression
title_full_unstemmed Robust and Sustained Effect of Ketamine Infusions Coadministered with Conventional Antidepressants in a Patient with Refractory Major Depression
title_short Robust and Sustained Effect of Ketamine Infusions Coadministered with Conventional Antidepressants in a Patient with Refractory Major Depression
title_sort robust and sustained effect of ketamine infusions coadministered with conventional antidepressants in a patient with refractory major depression
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364451/
https://www.ncbi.nlm.nih.gov/pubmed/25821622
http://dx.doi.org/10.1155/2015/815673
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