Cargando…

Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape

Dendritic cells (DCs) and macrophages (Møs) internalize and process exogenous HIV-derived antigens for cross-presentation by MHC-I to cytotoxic CD8(+) T cells (CTL). However, how degradation patterns of HIV antigens in the cross-presentation pathways affect immunodominance and immune escape is poorl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dinter, Jens, Duong, Ellen, Lai, Nicole Y., Berberich, Matthew J., Kourjian, Georgio, Bracho-Sanchez, Edith, Chu, Duong, Su, Hang, Zhang, Shao Chong, Le Gall, Sylvie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364612/ https://www.ncbi.nlm.nih.gov/pubmed/25781895 http://dx.doi.org/10.1371/journal.ppat.1004725

Ejemplares similares

Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design
por: Rucevic, Marijana, et al.
Publicado: (2014)

Variable processing and presentation of HIV epitopes in dendritic cells and macrophages to CD8 T cells
por: Gourdain, P, et al.
Publicado: (2012)

Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response
por: Troyer, Ryan M., et al.
Publicado: (2009)

Virus escape from CTL recognition
Publicado: (1994)

HIV CTL escape: at what cost?
por: Smith, Stephen M
Publicado: (2004)

Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection
por: Shimizu, Akihisa, et al.
Publicado: (2013)

Broad CTL Response in Early HIV Infection Drives Multiple Concurrent CTL Escapes
por: Leviyang, Sivan, et al.
Publicado: (2015)

CTL Escape and Viral Fitness in HIV/SIV Infection
por: Seki, Sayuri, et al.
Publicado: (2012)

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA
por: Leslie, Alasdair, et al.
Publicado: (2005)

Structured Observations Reveal Slow HIV-1 CTL Escape
por: Roberts, Hannah E., et al.
Publicado: (2015)

P09-10. Impact of CTL escape mutations in HIV-1 Nef on viral replication
por: Oniangue-Ndza, C, et al.
Publicado: (2009)

Estimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection
por: Ganusov, Vitaly V, et al.
Publicado: (2006)

CTL Escape Mediated by Proteasomal Destruction of an HIV-1 Cryptic Epitope
por: Cardinaud, Sylvain, et al.
Publicado: (2011)

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape
por: Kløverpris, Henrik N, et al.
Publicado: (2015)

In vitro evaluation of digestive and endolysosomal enzymes to cleave CML-modified Ara h 1 peptides
por: Mattison, Christopher P, et al.
Publicado: (2015)

A minimal T-cell immunogen designed to cover HIV-1 specificities associated with control is immunogenic in mice and breaks CTL immunodominance
por: Mothe, B, et al.
Publicado: (2012)

Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape
por: Karlsson, Annika C., et al.
Publicado: (2007)

Limited T Cell Receptor Diversity of HCV-specific T Cell Responses Is Associated with CTL Escape
por: Meyer-Olson, Dirk, et al.
Publicado: (2004)

Impact of transmitted CTL escape mutations on replicative capacity and HIV pathogenesis in early infection
por: Prince, J, et al.
Publicado: (2012)

Within-Epitope Interactions Can Bias CTL Escape Estimation in Early HIV Infection
por: Garcia, Victor, et al.
Publicado: (2017)

Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag
por: Carlson, Jonathan M., et al.
Publicado: (2008)

A novel category of antigens enabling CTL immunity to tumor escape variants: Cinderella antigens
por: Seidel, Ursula J. E., et al.
Publicado: (2011)

OA06-03. Dynamics of CTL epitope escape and reversion in an African subtype C cohort
por: Schaefer, M, et al.
Publicado: (2009)

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
por: Deng, Kai, et al.
Publicado: (2015)

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope
por: Cole, David K., et al.
Publicado: (2017)

Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage
por: Chopera, Denis R., et al.
Publicado: (2008)

Kinetics of HIV-Specific CTL Responses Plays a Minimal Role in Determining HIV Escape Dynamics
por: Yang, Yiding, et al.
Publicado: (2018)

AIDS virus–specific CD8(+) T lymphocytes against an immunodominant cryptic epitope select for viral escape
por: Maness, Nicholas J., et al.
Publicado: (2007)

Immunodominant antibody responses directed to SARS-CoV-2 hotspot mutation sites and risk of immune escape
por: Oliveira, Jamille Ramos, et al.
Publicado: (2023)

HIV Env conserved element DNA vaccine alters immunodominance in macaques
por: Hu, Xintao, et al.
Publicado: (2017)

Alteration of HIV epitope processing and presentation by HIV protease inhibitors
por: Kourjian, G, et al.
Publicado: (2012)

CTLA-4 blockade during dendritic cell based booster vaccination influences dendritic cell survival and CTL expansion
por: Pedersen, Anders E, et al.
Publicado: (2007)

A viral CTL escape mutation leading to immunoglobulin-like transcript 4–mediated functional inhibition of myelomonocytic cells
por: Lichterfeld, Mathias, et al.
Publicado: (2007)

Maintenance of viral suppression in HIV-1–infected HLA-B*57(+) elite suppressors despite CTL escape mutations
por: Bailey, Justin R., et al.
Publicado: (2006)

Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors
por: Yang, Yue, et al.
Publicado: (2010)

Genetic divergence of HIV-1 B subtype in Italy over the years 2003–2016 and impact on CTL escape prevalence
por: Alteri, Claudia, et al.
Publicado: (2018)

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity
Publicado: (1996)

P09-07. Balancing reversion of CTL and neutralizing antibody escape mutations within HIV-1 Env upon transmission
por: Peut, V, et al.
Publicado: (2009)

Cross-competition of CD8(+) T cells shapes the immunodominance hierarchy during boost vaccination
por: Kastenmuller, Wolfgang, et al.
Publicado: (2007)

Protein structure shapes immunodominance in the CD4 T cell response to yellow fever vaccination
por: Koblischke, Maximilian, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_uh8ntu52d4oii41ednbj22c4jn