An Rb1-dependent amplification loop between Ets1 and Zeb1 is evident in thymocyte differentiation and invasive lung adenocarcinoma

BACKGROUND: Ras pathway mutation leads to induction and Erk phosphorylation and activation of the Ets1 transcription factor. Ets1 in turn induces cyclin E and cyclin dependent kinase (cdk) 2 to drive cell cycle progression. Ets1 also induces expression of the epithelial-mesenchymal transition (EMT)...

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Detalles Bibliográficos
Autores principales: Dean, Kevin C, Huang, Li, Chen, Yao, Lu, Xiaoqin, Liu, Yongqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364651/
https://www.ncbi.nlm.nih.gov/pubmed/25880398
http://dx.doi.org/10.1186/s12867-015-0038-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364651/
https://www.ncbi.nlm.nih.gov/pubmed/25880398
http://dx.doi.org/10.1186/s12867-015-0038-4

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