Stromal Cells Positively and Negatively Modulate the Growth of Cancer Cells: Stimulation via the PGE2-TNFα-IL-6 Pathway and Inhibition via Secreted GAPDH-E-Cadherin Interaction

Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, but those factors are not fully understood. Here, we have identified critical stromal factors that modulate cancer growth positively and negatively. Using a cell co-culture system, we found that gastric stroma...

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Detalles Bibliográficos
Autores principales: Kawada, Manabu, Inoue, Hiroyuki, Ohba, Shun-ichi, Yoshida, Junjiro, Masuda, Tohru, Yamasaki, Manabu, Usami, Ihomi, Sakamoto, Shuichi, Abe, Hikaru, Watanabe, Takumi, Yamori, Takao, Shibasaki, Masakatsu, Nomoto, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364666/
https://www.ncbi.nlm.nih.gov/pubmed/25785838
http://dx.doi.org/10.1371/journal.pone.0119415

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