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EGFR Mutant Structural Database: computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib

BACKGROUND: Epidermal growth factor receptor (EGFR) mutation-induced drug resistance has caused great difficulties in the treatment of non-small-cell lung cancer (NSCLC). However, structural information is available for just a few EGFR mutants. In this study, we created an EGFR Mutant Structural Dat...

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Detalles Bibliográficos
Autores principales:	Ma, Lichun, Wang, Debby D, Huang, Yiqing, Yan, Hong, Wong, Maria P, Lee, Victor HF
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364680/ https://www.ncbi.nlm.nih.gov/pubmed/25886721 http://dx.doi.org/10.1186/s12859-015-0522-3

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