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The Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of Post-Receptoral Processing

We studied the spatial arrangement of L- and M-cone driven electroretinograms (ERGs) reflecting the activity of magno- and parvocellular pathways. L- and M-cone isolating sine wave stimuli were created with a four primary LED stimulator using triple silent substitution paradigms. Temporal frequencie...

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Autores principales: Jacob, Mellina M., Pangeni, Gobinda, Gomes, Bruno D., Souza, Givago S., da Silva Filho, Manoel, Silveira, Luiz Carlos L., Maguire, John, Parry, Neil R. A., McKeefry, Declan J., Kremers, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364754/
https://www.ncbi.nlm.nih.gov/pubmed/25785459
http://dx.doi.org/10.1371/journal.pone.0121218
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author Jacob, Mellina M.
Pangeni, Gobinda
Gomes, Bruno D.
Souza, Givago S.
da Silva Filho, Manoel
Silveira, Luiz Carlos L.
Maguire, John
Parry, Neil R. A.
McKeefry, Declan J.
Kremers, Jan
author_facet Jacob, Mellina M.
Pangeni, Gobinda
Gomes, Bruno D.
Souza, Givago S.
da Silva Filho, Manoel
Silveira, Luiz Carlos L.
Maguire, John
Parry, Neil R. A.
McKeefry, Declan J.
Kremers, Jan
author_sort Jacob, Mellina M.
collection PubMed
description We studied the spatial arrangement of L- and M-cone driven electroretinograms (ERGs) reflecting the activity of magno- and parvocellular pathways. L- and M-cone isolating sine wave stimuli were created with a four primary LED stimulator using triple silent substitution paradigms. Temporal frequencies were 8 and 12 Hz, to reflect cone opponent activity, and 30, 36 and 48 Hz to reflect luminance activity. The responses were measured for full-field stimuli and for different circular and annular stimuli. The ERG data confirm the presence of two different mechanisms at intermediate and high temporal frequencies. The responses measured at high temporal frequencies strongly depended upon spatial stimulus configuration. In the full-field conditions, the L-cone driven responses were substantially larger than the full-field M-cone driven responses and also than the L-cone driven responses with smaller stimuli. The M-cone driven responses at full-field and with 70° diameter stimuli displayed similar amplitudes. The L- and M-cone driven responses measured at 8 and 12 Hz were of similar amplitude and approximately in counter-phase. The amplitudes were constant for most stimulus configurations. The results indicate that, when the ERG reflects luminance activity, it is positively correlated with stimulus size. Beyond 35° retinal eccentricity, the retina mainly contains L-cones. Small stimuli are sufficient to obtain maximal ERGs at low temporal frequencies where the ERGs are also sensitive to cone-opponent processing.
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spelling pubmed-43647542015-03-23 The Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of Post-Receptoral Processing Jacob, Mellina M. Pangeni, Gobinda Gomes, Bruno D. Souza, Givago S. da Silva Filho, Manoel Silveira, Luiz Carlos L. Maguire, John Parry, Neil R. A. McKeefry, Declan J. Kremers, Jan PLoS One Research Article We studied the spatial arrangement of L- and M-cone driven electroretinograms (ERGs) reflecting the activity of magno- and parvocellular pathways. L- and M-cone isolating sine wave stimuli were created with a four primary LED stimulator using triple silent substitution paradigms. Temporal frequencies were 8 and 12 Hz, to reflect cone opponent activity, and 30, 36 and 48 Hz to reflect luminance activity. The responses were measured for full-field stimuli and for different circular and annular stimuli. The ERG data confirm the presence of two different mechanisms at intermediate and high temporal frequencies. The responses measured at high temporal frequencies strongly depended upon spatial stimulus configuration. In the full-field conditions, the L-cone driven responses were substantially larger than the full-field M-cone driven responses and also than the L-cone driven responses with smaller stimuli. The M-cone driven responses at full-field and with 70° diameter stimuli displayed similar amplitudes. The L- and M-cone driven responses measured at 8 and 12 Hz were of similar amplitude and approximately in counter-phase. The amplitudes were constant for most stimulus configurations. The results indicate that, when the ERG reflects luminance activity, it is positively correlated with stimulus size. Beyond 35° retinal eccentricity, the retina mainly contains L-cones. Small stimuli are sufficient to obtain maximal ERGs at low temporal frequencies where the ERGs are also sensitive to cone-opponent processing. Public Library of Science 2015-03-18 /pmc/articles/PMC4364754/ /pubmed/25785459 http://dx.doi.org/10.1371/journal.pone.0121218 Text en © 2015 Jacob et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jacob, Mellina M.
Pangeni, Gobinda
Gomes, Bruno D.
Souza, Givago S.
da Silva Filho, Manoel
Silveira, Luiz Carlos L.
Maguire, John
Parry, Neil R. A.
McKeefry, Declan J.
Kremers, Jan
The Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of Post-Receptoral Processing
title The Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of Post-Receptoral Processing
title_full The Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of Post-Receptoral Processing
title_fullStr The Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of Post-Receptoral Processing
title_full_unstemmed The Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of Post-Receptoral Processing
title_short The Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of Post-Receptoral Processing
title_sort spatial properties of l- and m-cone inputs to electroretinograms that reflect different types of post-receptoral processing
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364754/
https://www.ncbi.nlm.nih.gov/pubmed/25785459
http://dx.doi.org/10.1371/journal.pone.0121218
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