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Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage

Lamins A/C have been implicated in DNA damage response pathways. We show that the DNA repair protein 53BP1 is a lamin A/C binding protein. In undamaged human dermal fibroblasts (HDF), 53BP1 is a nucleoskeleton protein. 53BP1 binds to lamins A/C via its Tudor domain, and this is abrogated by DNA dama...

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Detalles Bibliográficos
Autores principales:	Gibbs-Seymour, Ian, Markiewicz, Ewa, Bekker-Jensen, Simon, Mailand, Niels, Hutchison, Christopher J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364828/ https://www.ncbi.nlm.nih.gov/pubmed/25645366 http://dx.doi.org/10.1111/acel.12258

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