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Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors
Aging-related emotional memory deficit is a well-known complication in Alzheimer's disease and normal aging. However, little is known about its molecular mechanism. To address this issue, we examined the role of norepinephrine (NE) and its relevant drug desipramine in the regulation of hippocam...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364829/ https://www.ncbi.nlm.nih.gov/pubmed/25564942 http://dx.doi.org/10.1111/acel.12282 |
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author | Luo, Yi Zhou, Jun Li, Ming-Xing Wu, Peng-Fei Hu, Zhuang-Li Ni, Lan Jin, You Chen, Jian-Guo Wang, Fang |
author_facet | Luo, Yi Zhou, Jun Li, Ming-Xing Wu, Peng-Fei Hu, Zhuang-Li Ni, Lan Jin, You Chen, Jian-Guo Wang, Fang |
author_sort | Luo, Yi |
collection | PubMed |
description | Aging-related emotional memory deficit is a well-known complication in Alzheimer's disease and normal aging. However, little is known about its molecular mechanism. To address this issue, we examined the role of norepinephrine (NE) and its relevant drug desipramine in the regulation of hippocampal long-term potentiation (LTP), surface expression of AMPA receptor, and associative fear memory in rats. We found that there was a defective regulation of NE content and AMPA receptor trafficking during fear conditioning, which were accompanied by impaired emotional memory and LTP in aged rats. Furthermore, we also found that the exogenous upregulation of NE ameliorated the impairment of LTP and emotional memory via enhancing AMPA receptor trafficking in aged rats, and the downregulation of NE impaired LTP in adult rats. Finally, acute treatment with NE or desipramine rescued the impaired emotional memory in aged rats. These results imply a pivotal role for NE in synaptic plasticity and associative fear memory in aging rats and suggest that desipramine is a potential candidate for treating aging-related emotional memory deficit. |
format | Online Article Text |
id | pubmed-4364829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43648292015-04-01 Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors Luo, Yi Zhou, Jun Li, Ming-Xing Wu, Peng-Fei Hu, Zhuang-Li Ni, Lan Jin, You Chen, Jian-Guo Wang, Fang Aging Cell Original Articles Aging-related emotional memory deficit is a well-known complication in Alzheimer's disease and normal aging. However, little is known about its molecular mechanism. To address this issue, we examined the role of norepinephrine (NE) and its relevant drug desipramine in the regulation of hippocampal long-term potentiation (LTP), surface expression of AMPA receptor, and associative fear memory in rats. We found that there was a defective regulation of NE content and AMPA receptor trafficking during fear conditioning, which were accompanied by impaired emotional memory and LTP in aged rats. Furthermore, we also found that the exogenous upregulation of NE ameliorated the impairment of LTP and emotional memory via enhancing AMPA receptor trafficking in aged rats, and the downregulation of NE impaired LTP in adult rats. Finally, acute treatment with NE or desipramine rescued the impaired emotional memory in aged rats. These results imply a pivotal role for NE in synaptic plasticity and associative fear memory in aging rats and suggest that desipramine is a potential candidate for treating aging-related emotional memory deficit. BlackWell Publishing Ltd 2015-04 2015-01-07 /pmc/articles/PMC4364829/ /pubmed/25564942 http://dx.doi.org/10.1111/acel.12282 Text en © 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Luo, Yi Zhou, Jun Li, Ming-Xing Wu, Peng-Fei Hu, Zhuang-Li Ni, Lan Jin, You Chen, Jian-Guo Wang, Fang Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors |
title | Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors |
title_full | Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors |
title_fullStr | Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors |
title_full_unstemmed | Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors |
title_short | Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors |
title_sort | reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface ampa receptors |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364829/ https://www.ncbi.nlm.nih.gov/pubmed/25564942 http://dx.doi.org/10.1111/acel.12282 |
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