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Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging

Chaperone-mediated autophagy (CMA), a cellular process that contributes to protein quality control through targeting of a subset of cytosolic proteins to lysosomes for degradation, undergoes a functional decline with age. We have used a mouse model with liver-specific defective CMA to identify chang...

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Detalles Bibliográficos
Autores principales:	Schneider, Jaime L, Villarroya, Joan, Diaz-Carretero, Antonio, Patel, Bindi, Urbanska, Aleksandra M, Thi, Mia M, Villarroya, Francesc, Santambrogio, Laura, Cuervo, Ana Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364837/ https://www.ncbi.nlm.nih.gov/pubmed/25620427 http://dx.doi.org/10.1111/acel.12310

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