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Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

The mechanism by which the drug rapamycin inhibits the mechanistic target of rapamycin (mTOR) is of intense interest because of its likely relevance in cancer biology, aging, and other age-related diseases. While rapamycin acutely and directly inhibits mTORC1, only chronic administration of rapamyci...

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Detalles Bibliográficos
Autores principales:	Schreiber, Katherine H, Ortiz, Denise, Academia, Emmeline C, Anies, Arieanna C, Liao, Chen-Yu, Kennedy, Brian K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364838/ https://www.ncbi.nlm.nih.gov/pubmed/25652038 http://dx.doi.org/10.1111/acel.12313

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