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A Mechanistic Tumor Penetration Model to Guide Antibody Drug Conjugate Design
Antibody drug conjugates (ADCs) represent novel anti-cancer modalities engineered to specifically target and kill tumor cells expressing corresponding antigens. Due to their large size and their complex kinetics, these therapeutic agents often face heterogeneous distributions in tumors, leading to l...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364906/ https://www.ncbi.nlm.nih.gov/pubmed/25786126 http://dx.doi.org/10.1371/journal.pone.0118977 |