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Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage

Aging and carcinogenesis coincide with the accumulation of DNA damage and mutations in stem and progenitor cells. Molecular mechanisms that influence responses of stem and progenitor cells to DNA damage remain to be delineated. Here, we show that niche positioning and Wnt signaling activity modulate...

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Detalles Bibliográficos
Autores principales:	Tao, Si, Tang, Duozhuang, Morita, Yohei, Sperka, Tobias, Omrani, Omid, Lechel, André, Sakk, Vadim, Kraus, Johann, Kestler, Hans A, Kühl, Michael, Rudolph, Karl Lenhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365032/ https://www.ncbi.nlm.nih.gov/pubmed/25609789 http://dx.doi.org/10.15252/embj.201490700

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