Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology

Loss of function mutations in granulin (GRN) are linked to two distinct neurological disorders, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). It is so far unknown how a complete loss of GRN in NCL and partial loss of GRN in FTLD can result in such distinct diseas...

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Detalles Bibliográficos
Autores principales: Solchenberger, Barbara, Russell, Claire, Kremmer, Elisabeth, Haass, Christian, Schmid, Bettina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365039/
https://www.ncbi.nlm.nih.gov/pubmed/25785851
http://dx.doi.org/10.1371/journal.pone.0118956

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