Cargando…

Obesity Impairs γδ T Cell Homeostasis and Antiviral Function in Humans

Obese patients are susceptible to increased morbidity and mortality associated with infectious diseases such as influenza A virus. γδ T cells and memory αβ T cells play key roles in reducing viral load by rapidly producing IFN-γ and lysing infected cells. In this article we analyze the impact of obe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Costanzo, Anne E., Taylor, Kristen R., Dutt, Shelley, Han, Peggy P., Fujioka, Ken, Jameson, Julie M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365046/ https://www.ncbi.nlm.nih.gov/pubmed/25785862 http://dx.doi.org/10.1371/journal.pone.0120918

Ejemplares similares

Dysfunctional γδ T cells contribute to impaired keratinocyte homeostasis in mouse models of obesity
por: Taylor, Kristen R., et al.
Publicado: (2011)

γδ T Cells Are Reduced and Rendered Unresponsive by Hyperglycemia and Chronic TNFα in Mouse Models of Obesity and Metabolic Disease
por: Taylor, Kristen R., et al.
Publicado: (2010)

mTOR Inhibition by Everolimus Does Not Impair Closure of Punch Biopsy Wounds in Renal Transplant Patients
por: Dutt, Shelley B., et al.
Publicado: (2017)

Chronic Inflammation and γδ T Cells
por: Fay, Nathan S., et al.
Publicado: (2016)

Antiviral reactivities of γδ T cells
por: Poccia, Fabrizio, et al.
Publicado: (2005)

Skin Resident γδ T Cell Function and Regulation in Wound Repair
por: Munoz, Luis D., et al.
Publicado: (2020)

Human αβ and γδ T Cells in Skin Immunity and Disease
por: Cruz, Michelle S., et al.
Publicado: (2018)

γδ T cells: A disappearing act with a big reveal
por: Jameson, Julie M.
Publicado: (2018)

γδ T Cells in Brain Homeostasis and Diseases
por: Park, Jang Hyun, et al.
Publicado: (2022)

The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis
por: Jabeen, Rukhsana, et al.
Publicado: (2011)

Double-edged sword: γδ T cells in mucosal homeostasis and disease
por: Kang, In, et al.
Publicado: (2023)

γδ T cell–induced hyaluronan production by epithelial cells regulates inflammation
por: Jameson, Julie M., et al.
Publicado: (2005)

Impairment of antigen-presenting function of peripheral γδ T cells in patients with sepsis
por: Yang, Xue-Wei, et al.
Publicado: (2021)

Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions
por: Deseke, Malte, et al.
Publicado: (2020)

Regeneration during Obesity: An Impaired Homeostasis
por: Ghanemi, Abdelaziz, et al.
Publicado: (2020)

Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis
por: Krishnan, Siddharth, et al.
Publicado: (2018)

A Functional γδTCR/CD3 Complex Distinct from γδT Cells Is Expressed by Human Eosinophils
por: Legrand, Fanny, et al.
Publicado: (2009)

Role of Galectin-3 in Obesity and Impaired Glucose Homeostasis
por: Menini, Stefano, et al.
Publicado: (2016)

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy
por: Legut, Mateusz, et al.
Publicado: (2015)

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
por: Muro, Ryunosuke, et al.
Publicado: (2023)

Integral Roles for Integrins in γδ T Cell Function
por: Siegers, Gabrielle M.
Publicado: (2018)

Skin γδ T Cells and Their Function in Wound Healing
por: Hu, Wengang, et al.
Publicado: (2022)

γδ T cells in cancer immunotherapy
por: Zou, Chang, et al.
Publicado: (2016)

Interleukin‐17‐producing γδ T (γδ17) cells in inflammatory diseases
por: Akitsu, Aoi, et al.
Publicado: (2018)

γδ T Cell-Mediated Immunity to Cytomegalovirus Infection
por: Khairallah, Camille, et al.
Publicado: (2017)

The Aging of γδ T Cells
por: Xu, Weili, et al.
Publicado: (2020)

Vitamin C promotes the proliferation and effector functions of human γδ T cells
por: Kouakanou, Léonce, et al.
Publicado: (2019)

Obesity-Associated Hepatosteatosis and Impairment of Glucose Homeostasis Are Attenuated by Haptoglobin Deficiency
por: Lisi, Simonetta, et al.
Publicado: (2011)

Re-generation of cytotoxic γδT cells with distinctive signatures from human γδT-derived iPSCs
por: Murai, Nobuyuki, et al.
Publicado: (2023)

Bordeaux 2018: Wine, Cheese, and γδ T Cells
por: Edelblum, Karen, et al.
Publicado: (2019)

Recent advances in understanding the development and function of γδ T cells
por: Contreras, Alejandra V., et al.
Publicado: (2020)

The intestinal γδ T cells: functions in the gut and in the distant organs
por: Li, Guo-Qing, et al.
Publicado: (2023)

Immunotherapy of acute myeloid leukemia based on γδ T cells
por: Gertner-Dardenne, Julie, et al.
Publicado: (2012)

Monitoring Circulating γδ T Cells in Cancer Patients to Optimize γδ T Cell-Based Immunotherapy
por: Oberg, Hans-Heinrich, et al.
Publicado: (2014)

Imbalance of γδT17/γδTreg cells in the pathogenesis of allergic asthma induced by ovalbumin
por: Yang, Xia, et al.
Publicado: (2018)

Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity
por: Gully, Benjamin S., et al.
Publicado: (2021)

Human γδ TCR Repertoires in Health and Disease
por: Fichtner, Alina Suzann, et al.
Publicado: (2020)

Hepatocellular carcinoma‐infiltrating γδ T cells are functionally defected and allogenic Vδ2(+) γδ T cell can be a promising complement
por: He, Wenjing, et al.
Publicado: (2022)

SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or γδ T cells
por: Singh, Kiran, et al.
Publicado: (2022)

γδ T cells take on CMV
por: Van Epps, Heather L.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_rmjqlvlmqlqa499cu986h1o2nm