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Two Arginine Residues Suppress the Flexibility of Nucleosomal DNA in the Canonical Nucleosome Core
The dynamics of nucleosomes containing either canonical H3 or its centromere-specific variant CENP-A were investigated using molecular dynamics simulations. The simulations showed that the histone cores were structurally stable during simulation periods of 100 ns and 50 ns, while DNA was highly flex...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365049/ https://www.ncbi.nlm.nih.gov/pubmed/25786215 http://dx.doi.org/10.1371/journal.pone.0120635 |