Cargando…

Understanding the effect of alternative splicing in the folding and function of the second PDZ from Protein Tyrosine Phosphatase-BL

PDZ domains are the most prominent biological structural domains involved in protein-protein interactions in the human cell. The second PDZ domain of the protein tyrosine phosphatase BL (PDZ2) interacts and binds the C-termini of the tumour suppressor protein APC and of the LIM domain-containing pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Silvio, Eva, Toto, Angelo, Bonetti, Daniela, Morrone, Angela, Gianni, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365404/ https://www.ncbi.nlm.nih.gov/pubmed/25788329 http://dx.doi.org/10.1038/srep09299

Ejemplares similares

Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains
por: Caillet-Saguy, Célia, et al.
Publicado: (2017)

Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
por: Hultqvist, Greta, et al.
Publicado: (2012)

Understanding the Binding Induced Folding of Intrinsically Disordered Proteins by Protein Engineering: Caveats and Pitfalls
por: Malagrinò, Francesca, et al.
Publicado: (2020)

Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95
por: Gautier, Candice, et al.
Publicado: (2017)

Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2
por: Toto, Angelo, et al.
Publicado: (2017)

Zasp: A New Z-Band Alternatively Spliced PDZ-Motif Protein
por: Faulkner, Georgine, et al.
Publicado: (1999)

Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer
por: Nardella, Caterina, et al.
Publicado: (2021)

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity
por: Genera, Mariano, et al.
Publicado: (2023)

The kinetics of folding of the NSH2 domain from p85
por: Visconti, Lorenzo, et al.
Publicado: (2019)

Towards a structural biology of the hydrophobic effect in protein folding
por: Camilloni, Carlo, et al.
Publicado: (2016)

Seeking allosteric networks in PDZ domains
por: Gautier, Candice, et al.
Publicado: (2018)

Comparing the binding properties of peptides mimicking the Envelope protein of SARS‐CoV and SARS‐CoV‐2 to the PDZ domain of the tight junction‐associated PALS1 protein
por: Toto, Angelo, et al.
Publicado: (2020)

Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein
por: Toto, Angelo, et al.
Publicado: (2016)

The FERM and PDZ Domain-Containing Protein Tyrosine Phosphatases, PTPN4 and PTPN3, Are Both Dispensable for T Cell Receptor Signal Transduction
por: Bauler, Timothy J., et al.
Publicado: (2008)

Double Mutant Cycles as a Tool to Address Folding, Binding, and Allostery
por: Pagano, Livia, et al.
Publicado: (2021)

Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains
por: Santorelli, Daniele, et al.
Publicado: (2023)

The Effect of Proline cis-trans Isomerization on the Folding of the C-Terminal SH2 Domain from p85
por: Troilo, Francesca, et al.
Publicado: (2019)

Determining folding and binding properties of the C‐terminal SH2 domain of SHP2
por: Nardella, Caterina, et al.
Publicado: (2021)

Mapping the allosteric network within a SH3 domain
por: Malagrinò, Francesca, et al.
Publicado: (2019)

Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain
Publicado: (1996)

The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain
por: Pedersen, Søren W., et al.
Publicado: (2014)

The cooperative folding of annexin A2 relies on a transient nonnative intermediate
por: Hollås, Hanne, et al.
Publicado: (2022)

SH2 Domains: Folding, Binding and Therapeutical Approaches
por: Diop, Awa, et al.
Publicado: (2022)

Genomic structure and alternative splicing of murine R2B receptor protein tyrosine phosphatases (PTPκ, μ, ρ and PCP-2)
por: Besco, Julie, et al.
Publicado: (2004)

Different electrostatic forces drive the binding kinetics of SARS-CoV, SARS-CoV-2 and MERS-CoV Envelope proteins with the PDZ2 domain of ZO1
por: Pennacchietti, Valeria, et al.
Publicado: (2023)

On the Effects of Disordered Tails, Supertertiary Structure and Quinary Interactions on the Folding and Function of Protein Domains
por: Malagrinò, Francesca, et al.
Publicado: (2022)

Characterization of early and late transition states of the folding pathway of a SH2 domain
por: Toto, Angelo, et al.
Publicado: (2022)

Folding and Binding Mechanisms of the SH2 Domain from Crkl
por: Nardella, Caterina, et al.
Publicado: (2022)

LAR tyrosine phosphatase receptor: alternative splicing is preferential to the nervous system, coordinated with cell growth and generates novel isoforms containing extensive CAG repeats
Publicado: (1995)

Understanding and repurposing CRISPR-mediated alternative splicing
por: Smith, Jordan L., et al.
Publicado: (2018)

Expression of LIM domain-binding 3 (LDB3), a striated muscle Z-band alternatively spliced PDZ-motif protein in the nervous system
por: Blech-Hermoni, Yotam, et al.
Publicado: (2023)

Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate
por: Gautier, Candice, et al.
Publicado: (2020)

Allosterism in the PDZ Family
por: Stevens, Amy O., et al.
Publicado: (2022)

Alternative splicing of spleen tyrosine kinase differentially regulates colorectal cancer progression
por: Ni, Beibei, et al.
Publicado: (2016)

Accurate Prediction of the Dynamical Changes within the Second PDZ Domain of PTP1e
por: Cilia, Elisa, et al.
Publicado: (2012)

The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR
por: O'Grady, Pauline, et al.
Publicado: (1998)

A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis
por: Bilotta, Anna, et al.
Publicado: (2016)

Structural determinants driving the binding process between PDZ domain of wild type human PALS1 protein and SLiM sequences of SARS-CoV E proteins
por: Lo Cascio, Ettore, et al.
Publicado: (2021)

Protein tyrosine phosphatases in glioma biology
por: Navis, Anna C., et al.
Publicado: (2009)

Metabolic regulation by protein tyrosine phosphatases
por: Knobler, Hilla, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qdcbbp9j405gb4sufg5npt84pj