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Highly efficient gene knockout by injection of TALEN mRNAs into oocytes and host transfer in Xenopus laevis
Zinc-finger nucleases, transcription activator-like effector nucleases (TALENs) and the CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins) system are potentially powerful tools for producing tailor-made knockout animals. However, their mutagenic activit...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Company of Biologists
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365486/ https://www.ncbi.nlm.nih.gov/pubmed/25596277 http://dx.doi.org/10.1242/bio.201410009 |