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Highly efficient gene knockout by injection of TALEN mRNAs into oocytes and host transfer in Xenopus laevis

Zinc-finger nucleases, transcription activator-like effector nucleases (TALENs) and the CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins) system are potentially powerful tools for producing tailor-made knockout animals. However, their mutagenic activit...

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Detalles Bibliográficos
Autores principales: Nakajima, Keisuke, Yaoita, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365486/
https://www.ncbi.nlm.nih.gov/pubmed/25596277
http://dx.doi.org/10.1242/bio.201410009

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