Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway

BACKGROUND: Toll-like receptors (TLR) constitute a highly conserved class of receptors through which the innate immune system responds to both pathogen- and host-derived factors. Although TLRs are involved in a wide range of central nervous system (CNS) disorders including neurodegenerative diseases...

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Detalles Bibliográficos
Autores principales: Rosenberger, Karen, Dembny, Paul, Derkow, Katja, Engel, Odilo, Krüger, Christina, Wolf, Susanne A, Kettenmann, Helmut, Schott, Eckart, Meisel, Andreas, Lehnardt, Seija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365525/
https://www.ncbi.nlm.nih.gov/pubmed/25887709
http://dx.doi.org/10.1186/s13024-015-0003-1

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