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Dysregulated serum response factor triggers formation of hepatocellular carcinoma

The ubiquitously expressed transcriptional regulator serum response factor (SRF) is controlled by both Ras/MAPK (mitogen-activated protein kinase) and Rho/actin signaling pathways, which are frequently activated in hepatocellular carcinoma (HCC). We generated SRF-VP16(iHep) mice, which conditionally...

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Detalles Bibliográficos
Autores principales:	Ohrnberger, Stefan, Thavamani, Abhishek, Braeuning, Albert, Lipka, Daniel B, Kirilov, Milen, Geffers, Robert, Authenrieth, Stella E, Römer, Michael, Zell, Andreas, Bonin, Michael, Schwarz, Michael, Schütz, Günther, Schirmacher, Peter, Plass, Christoph, Longerich, Thomas, Nordheim, Alfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Hepatobiliary Malignancies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365683/ https://www.ncbi.nlm.nih.gov/pubmed/25266280 http://dx.doi.org/10.1002/hep.27539

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