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A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model

In this essay, we aim to explore in depth the new concept of the hypothalamus that was presented in the updated prosomeric model (Puelles et al., 2012b; Allen Developing Mouse Brain Atlas). Initial sections deal with the antecedents of prosomeric ideas represented by the extensive literature centere...

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Detalles Bibliográficos
Autores principales: Puelles, Luis, Rubenstein, John L. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365718/
https://www.ncbi.nlm.nih.gov/pubmed/25852489
http://dx.doi.org/10.3389/fnana.2015.00027
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author Puelles, Luis
Rubenstein, John L. R.
author_facet Puelles, Luis
Rubenstein, John L. R.
author_sort Puelles, Luis
collection PubMed
description In this essay, we aim to explore in depth the new concept of the hypothalamus that was presented in the updated prosomeric model (Puelles et al., 2012b; Allen Developing Mouse Brain Atlas). Initial sections deal with the antecedents of prosomeric ideas represented by the extensive literature centered on the alternative columnar model of Herrick (1910), Kuhlenbeck (1973) and Swanson (1992, 2003); a detailed critique explores why the columnar model is not helpful in the search for causal developmental explanations. In contrast, the emerging prosomeric scenario visibly includes many possibilities to propose causal explanations of hypothalamic structure relative to both anteroposterior and dorsoventral patterning mechanisms, and insures the possibility to compare hypothalamic histogenesis with that of more caudal parts of the brain. Next the four major changes introduced in the organization of the hypothalamus on occasion of the updated model are presented, and our rationale for these changes is explored in detail. It is hoped that this example of morphological theoretical analysis may be useful for readers interested in brain models, or in understanding why models may need to change in the quest for higher consistency.
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spelling pubmed-43657182015-04-07 A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model Puelles, Luis Rubenstein, John L. R. Front Neuroanat Neuroscience In this essay, we aim to explore in depth the new concept of the hypothalamus that was presented in the updated prosomeric model (Puelles et al., 2012b; Allen Developing Mouse Brain Atlas). Initial sections deal with the antecedents of prosomeric ideas represented by the extensive literature centered on the alternative columnar model of Herrick (1910), Kuhlenbeck (1973) and Swanson (1992, 2003); a detailed critique explores why the columnar model is not helpful in the search for causal developmental explanations. In contrast, the emerging prosomeric scenario visibly includes many possibilities to propose causal explanations of hypothalamic structure relative to both anteroposterior and dorsoventral patterning mechanisms, and insures the possibility to compare hypothalamic histogenesis with that of more caudal parts of the brain. Next the four major changes introduced in the organization of the hypothalamus on occasion of the updated model are presented, and our rationale for these changes is explored in detail. It is hoped that this example of morphological theoretical analysis may be useful for readers interested in brain models, or in understanding why models may need to change in the quest for higher consistency. Frontiers Media S.A. 2015-03-19 /pmc/articles/PMC4365718/ /pubmed/25852489 http://dx.doi.org/10.3389/fnana.2015.00027 Text en Copyright © 2015 Puelles and Rubenstein. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Puelles, Luis
Rubenstein, John L. R.
A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model
title A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model
title_full A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model
title_fullStr A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model
title_full_unstemmed A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model
title_short A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model
title_sort new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365718/
https://www.ncbi.nlm.nih.gov/pubmed/25852489
http://dx.doi.org/10.3389/fnana.2015.00027
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