High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer

BACKGROUND: Colorectal cancer with metastases limited to the liver (liver-limited mCRC) is a distinct clinical subset characterized by possible cure with surgery. We performed high-depth sequencing of over 750 cancer-associated genes and copy number profiling in matched primary, metastasis and norma...

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Detalles Bibliográficos
Autores principales: Tan, Iain Beehuat, Malik, Simeen, Ramnarayanan, Kalpana, McPherson, John R, Ho, Dan Liang, Suzuki, Yuka, Ng, Sarah Boonhsui, Yan, Su, Lim, Kiat Hon, Koh, Dennis, Hoe, Chew Min, Chan, Chung Yip, Ten, Rachel, Goh, Brian KP, Chung, Alexander YF, Tan, Joanna, Chan, Cheryl Xueli, Tay, Su Ting, Alexander, Lezhava, Nagarajan, Niranjan, Hillmer, Axel M, Tang, Choon Leong, Chua, Clarinda, Teh, Bin Tean, Rozen, Steve, Tan, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365969/
https://www.ncbi.nlm.nih.gov/pubmed/25808843
http://dx.doi.org/10.1186/s13059-015-0589-1

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