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A Genome-Wide siRNA Screen in Mammalian Cells for Regulators of S6 Phosphorylation

mTOR complex1, the major regulator of mRNA translation in all eukaryotic cells, is strongly activated in most cancers. We performed a genome-wide RNAi screen in a human cancer cell line, seeking genes that regulate S6 phosphorylation, readout of mTORC1 activity. Applying a stringent selection, we re...

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Detalles Bibliográficos
Autores principales:	Papageorgiou, Angela, Rapley, Joseph, Mesirov, Jill P., Tamayo, Pablo, Avruch, Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366019/ https://www.ncbi.nlm.nih.gov/pubmed/25790369 http://dx.doi.org/10.1371/journal.pone.0116096

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