Smoking p66Shc Knocked Out Mice Develop Respiratory Bronchiolitis with Fibrosis but Not Emphysema

The adaptor protein p66Shc regulates intracellular oxidant levels through the modulation of a forkhead-related transcription factor (FOXO3a). The genetic ablation of p66(Shc) (p66(Shc–/–)) renders mice resistant to oxidative stress and p53-dependent apoptosis. We investigated whether p66(Shc) ablati...

Descripción completa

Detalles Bibliográficos
Autores principales: Lunghi, Benedetta, De Cunto, Giovanna, Cavarra, Eleonora, Fineschi, Silvia, Bartalesi, Barbara, Lungarella, Giuseppe, Lucattelli, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366108/
https://www.ncbi.nlm.nih.gov/pubmed/25790295
http://dx.doi.org/10.1371/journal.pone.0119797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366108/
https://www.ncbi.nlm.nih.gov/pubmed/25790295
http://dx.doi.org/10.1371/journal.pone.0119797

Ejemplares similares