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Smoking p66Shc Knocked Out Mice Develop Respiratory Bronchiolitis with Fibrosis but Not Emphysema
The adaptor protein p66Shc regulates intracellular oxidant levels through the modulation of a forkhead-related transcription factor (FOXO3a). The genetic ablation of p66(Shc) (p66(Shc–/–)) renders mice resistant to oxidative stress and p53-dependent apoptosis. We investigated whether p66(Shc) ablati...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366108/ https://www.ncbi.nlm.nih.gov/pubmed/25790295 http://dx.doi.org/10.1371/journal.pone.0119797 |