Two Half-Sandwiched Ruthenium (II) Compounds Containing 5-Fluorouracil Derivatives: Synthesis and Study of DNA Intercalation

Two novel coordination compounds of half-sandwiched ruthenium(II) containing 2-(5-fluorouracil)-yl-N-(pyridyl)-acetamide were synthesized, and their intercalation binding modes with calf thymus DNA were revealed by hyperchromism of ultraviolet-visible spectroscopy; the binding constants were determi...

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Autores principales: Li, Zhao-Jun, Hou, Yong, Qin, Da-An, Jin, Zhi-Min, Hu, Mao-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366203/
https://www.ncbi.nlm.nih.gov/pubmed/25789618
http://dx.doi.org/10.1371/journal.pone.0120211
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author Li, Zhao-Jun
Hou, Yong
Qin, Da-An
Jin, Zhi-Min
Hu, Mao-Lin
author_facet Li, Zhao-Jun
Hou, Yong
Qin, Da-An
Jin, Zhi-Min
Hu, Mao-Lin
author_sort Li, Zhao-Jun
collection PubMed
description Two novel coordination compounds of half-sandwiched ruthenium(II) containing 2-(5-fluorouracil)-yl-N-(pyridyl)-acetamide were synthesized, and their intercalation binding modes with calf thymus DNA were revealed by hyperchromism of ultraviolet-visible spectroscopy; the binding constants were determined according to a Langmuir adsorption equation that was deduced on the base of careful cyclic voltammetry measurements. The two compounds exhibited DNA intercalation binding activities with the binding constants of 1.13×10(6) M(-1) and 5.35 ×10(5) M(-1), respectively.
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spelling pubmed-43662032015-03-23 Two Half-Sandwiched Ruthenium (II) Compounds Containing 5-Fluorouracil Derivatives: Synthesis and Study of DNA Intercalation Li, Zhao-Jun Hou, Yong Qin, Da-An Jin, Zhi-Min Hu, Mao-Lin PLoS One Research Article Two novel coordination compounds of half-sandwiched ruthenium(II) containing 2-(5-fluorouracil)-yl-N-(pyridyl)-acetamide were synthesized, and their intercalation binding modes with calf thymus DNA were revealed by hyperchromism of ultraviolet-visible spectroscopy; the binding constants were determined according to a Langmuir adsorption equation that was deduced on the base of careful cyclic voltammetry measurements. The two compounds exhibited DNA intercalation binding activities with the binding constants of 1.13×10(6) M(-1) and 5.35 ×10(5) M(-1), respectively. Public Library of Science 2015-03-19 /pmc/articles/PMC4366203/ /pubmed/25789618 http://dx.doi.org/10.1371/journal.pone.0120211 Text en © 2015 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Li, Zhao-Jun
Hou, Yong
Qin, Da-An
Jin, Zhi-Min
Hu, Mao-Lin
Two Half-Sandwiched Ruthenium (II) Compounds Containing 5-Fluorouracil Derivatives: Synthesis and Study of DNA Intercalation
title Two Half-Sandwiched Ruthenium (II) Compounds Containing 5-Fluorouracil Derivatives: Synthesis and Study of DNA Intercalation
title_full Two Half-Sandwiched Ruthenium (II) Compounds Containing 5-Fluorouracil Derivatives: Synthesis and Study of DNA Intercalation
title_fullStr Two Half-Sandwiched Ruthenium (II) Compounds Containing 5-Fluorouracil Derivatives: Synthesis and Study of DNA Intercalation
title_full_unstemmed Two Half-Sandwiched Ruthenium (II) Compounds Containing 5-Fluorouracil Derivatives: Synthesis and Study of DNA Intercalation
title_short Two Half-Sandwiched Ruthenium (II) Compounds Containing 5-Fluorouracil Derivatives: Synthesis and Study of DNA Intercalation
title_sort two half-sandwiched ruthenium (ii) compounds containing 5-fluorouracil derivatives: synthesis and study of dna intercalation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366203/
https://www.ncbi.nlm.nih.gov/pubmed/25789618
http://dx.doi.org/10.1371/journal.pone.0120211
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