Cargando…

Cloning, Identification and Functional Characterization of Bovine Free Fatty Acid Receptor-1 (FFAR1/GPR40) in Neutrophils

Long chain fatty acids (LCFAs), which are ligands for the G-protein coupled receptor FFAR1 (GPR40), are increased in cow plasma after parturition, a period in which they are highly susceptible to infectious diseases. This study identified and analyzed the functional role of the FFAR1 receptor in bov...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manosalva, Carolina, Mena, Jaqueline, Velasquez, Zahady, Colenso, Charlotte K., Brauchi, Sebastian, Burgos, Rafael A., Hidalgo, Maria A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366208/ https://www.ncbi.nlm.nih.gov/pubmed/25790461 http://dx.doi.org/10.1371/journal.pone.0119715

Ejemplares similares

Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice
por: Nakamoto, Kazuo, et al.
Publicado: (2017)

Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
por: Lückmann, Michael, et al.
Publicado: (2019)

Evaluation of the hepatotoxicity of the novel GPR40 (FFAR1) agonist CPL207280 in the rat and monkey
por: Bazydlo-Guzenda, Katarzyna, et al.
Publicado: (2021)

Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine
por: Christensen, Louise W, et al.
Publicado: (2015)

PS04. The changes of emotional behavior in a free fatty acid receptor 1, GPR40/FFAR1, deficient mice
por: Aizawa, Fuka, et al.
Publicado: (2016)

PT640. The dysfunction of brain free fatty acid receptor GPR40/FFAR1 signaling relate to the development of chronic pain
por: Nakamoto, Kazuo, et al.
Publicado: (2016)

Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet–Induced Metabolic Disease
por: Lan, Hong, et al.
Publicado: (2008)

FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice
por: Sadamura, Yuko, et al.
Publicado: (2021)

GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo
por: Hauge, Maria, et al.
Publicado: (2014)

A novel free fatty acid receptor 1 (GPR40/FFAR1) agonist, MR1704, enhances glucose‐dependent insulin secretion and improves glucose homeostasis in rats
por: Tsuda, Naoto, et al.
Publicado: (2017)

A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes
por: Chen, Yanyun, et al.
Publicado: (2016)

The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids
por: Nagasawa, Tomotaka, et al.
Publicado: (2021)

EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4
por: Kamata, Ryo, et al.
Publicado: (2016)

Fasiglifam (TAK‐875) has dual potentiating mechanisms via Gαq‐GPR40/FFAR1 signaling branches on glucose‐dependent insulin secretion
por: Sakuma, Kensuke, et al.
Publicado: (2016)

Molecular mechanism of fatty acid activation of FFAR1
por: Kumari, Punita, et al.
Publicado: (2023)

FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids
por: Pærregaard, Simone Isling, et al.
Publicado: (2016)

FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing
por: Ang, Zhiwei, et al.
Publicado: (2018)

Molecular characterization of free fatty acid receptors FFAR2 and FFAR3 in the domestic cat
por: Yamamoto, Ichiro, et al.
Publicado: (2020)

Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT
por: Husted, Anna Sofie, et al.
Publicado: (2020)

GPR120/FFAR4 Pharmacology: Focus on Agonists in Type 2 Diabetes Mellitus Drug Discovery
por: Carullo, Gabriele, et al.
Publicado: (2021)

Expression of FFAR3 and FFAR4 Is Increased in Gastroesophageal Reflux Disease
por: Fabisiak, Adam, et al.
Publicado: (2020)

d(−) Lactic Acid-Induced Adhesion of Bovine Neutrophils onto Endothelial Cells Is Dependent on Neutrophils Extracellular Traps Formation and CD11b Expression
por: Alarcón, Pablo, et al.
Publicado: (2017)

Mechanistic Studies on the Stereoselectivity of FFAR1 Modulators
por: Teng, Dan, et al.
Publicado: (2022)

Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40
por: Hidalgo, Jorge, et al.
Publicado: (2017)

Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action
por: Lückmann, Michael, et al.
Publicado: (2022)

Simultaneous and Positively Correlated NET Formation and Autophagy in Besnoitia besnoiti Tachyzoite-Exposed Bovine Polymorphonuclear Neutrophils
por: Zhou, Ershun, et al.
Publicado: (2019)

Polymorphisms in FFAR4 (GPR120) Gene Modulate Insulin Levels and Sensitivity after Fish Oil Supplementation
por: Vallée Marcotte, Bastien, et al.
Publicado: (2017)

Omega-3 Fatty Acids and FFAR4
por: Oh, Da Young, et al.
Publicado: (2014)

Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2
por: Fachi, José Luís, et al.
Publicado: (2019)

The allosterically modulated FFAR2 is transactivated by signals generated by other neutrophil GPCRs
por: Lind, Simon, et al.
Publicado: (2023)

Trypanosoma brucei brucei Induces Polymorphonuclear Neutrophil Activation and Neutrophil Extracellular Traps Release
por: Grob, Daniela, et al.
Publicado: (2020)

Effect of short chain fatty acids on the expression of free fatty acid receptor 2 (Ffar2), Ffar3 and early-stage adipogenesis
por: Frost, G, et al.
Publicado: (2014)

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans
por: Stone, Virginia M., et al.
Publicado: (2014)

Eimeria bovis infections induce G(1) cell cycle arrest and a senescence-like phenotype in endothelial host cells
por: Velásquez, Zahady D., et al.
Publicado: (2021)

Variants in the FFAR1 Gene Are Associated with Beta Cell Function
por: Kalis, Martins, et al.
Publicado: (2007)

Metabolic Reprogramming and Inflammatory Response Induced by D-Lactate in Bovine Fibroblast-Like Synoviocytes Depends on HIF-1 Activity
por: Quiroga, John, et al.
Publicado: (2021)

Histone H2A and Bovine Neutrophil Extracellular Traps Induce Damage of Besnoitia besnoiti-Infected Host Endothelial Cells but Fail to Affect Total Parasite Proliferation
por: Conejeros, Iván, et al.
Publicado: (2019)

Ginseng Gintonin Contains Ligands for GPR40 and GPR55
por: Cho, Yeon-Jin, et al.
Publicado: (2020)

An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis
por: Sivaprakasam, S, et al.
Publicado: (2016)

Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells
por: Peiris, Madusha, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n2om1ft9du0f498pi1dhffijff