Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53

The downstream functions of the DNA binding tumor suppressor p53 vary depending on the cellular context, and persistent p53 activation has recently been implicated in tumor suppression and senescence. However, genome-wide information about p53-target gene regulation has been derived mostly from acut...

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Detalles Bibliográficos
Autores principales: Kirschner, Kristina, Samarajiwa, Shamith A., Cairns, Jonathan M., Menon, Suraj, Pérez-Mancera, Pedro A., Tomimatsu, Kosuke, Bermejo-Rodriguez, Camino, Ito, Yoko, Chandra, Tamir, Narita, Masako, Lyons, Scott K., Lynch, Andy G., Kimura, Hiroshi, Ohbayashi, Tetsuya, Tavaré, Simon, Narita, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366240/
https://www.ncbi.nlm.nih.gov/pubmed/25790137
http://dx.doi.org/10.1371/journal.pgen.1005053

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