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Pharmacokinetics (PK), Pharmacodynamics (PD) and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice

Pharmacological administration of fibroblast growth factor 21 (FGF21) improves metabolic profile in preclinical species and humans. FGF21 exerts its metabolic effects through formation of beta-klotho (KLB)/FGF receptor 1c FGFR1c complex and subsequent signaling. Data from various in vitro systems de...

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Detalles Bibliográficos
Autores principales:	Weng, Yan, Chabot, Jeffrey R., Bernardo, Barbara, Yan, Qingyun, Zhu, Yimin, Brenner, Martin B., Vage, Chandra, Logan, Alison, Calle, Roberto, Talukdar, Saswata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366384/ https://www.ncbi.nlm.nih.gov/pubmed/25790234 http://dx.doi.org/10.1371/journal.pone.0119104

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