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Spatial Heterogeneity in Drug Concentrations Can Facilitate the Emergence of Resistance to Cancer Therapy

Acquired resistance is one of the major barriers to successful cancer therapy. The development of resistance is commonly attributed to genetic heterogeneity. However, heterogeneity of drug penetration of the tumor microenvironment both on the microscopic level within solid tumors as well as on the m...

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Detalles Bibliográficos
Autores principales:	Fu, Feng, Nowak, Martin A., Bonhoeffer, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366398/ https://www.ncbi.nlm.nih.gov/pubmed/25789469 http://dx.doi.org/10.1371/journal.pcbi.1004142

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