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Gp78, an E3 Ubiquitin Ligase Acts as a Gatekeeper Suppressing Nonalcoholic Steatohepatitis (NASH) and Liver Cancer
Nonalcoholic steatohepatitis (NASH) is related to metabolic dysregulation and the perturbation of endoplasmic reticulum (ER) homeostasis that frequently develops into hepatocellular carcinoma (HCC). Gp78 is E3 ligase, which regulates endoplasmic reticulum-associated degradation (ERAD) by ubiquitinyl...
Autores principales: | Zhang, Tianpeng, Kho, Dhong Hyo, Wang, Ying, Harazono, Yosuke, Nakajima, Kosei, Xie, Youming, Raz, Avraham |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366401/ https://www.ncbi.nlm.nih.gov/pubmed/25789613 http://dx.doi.org/10.1371/journal.pone.0118448 |
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