Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia

Despite recent advances in the cure rate of acute lymphoblastic leukaemia (ALL), the prognosis for patients with relapsed ALL remains poor. Here we identify FOXM1 as a candidate responsible for an aggressive clinical course. We show that FOXM1 levels peak at the pre-B-cell receptor checkpoint but ar...

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Detalles Bibliográficos
Autores principales: Buchner, Maike, Park, Eugene, Geng, Huimin, Klemm, Lars, Flach, Johanna, Passegué, Emmanuelle, Schjerven, Hilde, Melnick, Ari, Paietta, Elisabeth, Kopanja, Dragana, Raychaudhuri, Pradip, Müschen, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366523/
https://www.ncbi.nlm.nih.gov/pubmed/25753524
http://dx.doi.org/10.1038/ncomms7471

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