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PKD1 Mono-Allelic Knockout Is Sufficient to Trigger Renal Cystogenesis in a Mini-Pig Model

PKD1 and PKD2 mutations could lead to autosomal dominant polycystic kidney disease (ADPKD), which afflicts millions of people worldwide. Due to the marked differences in the lifespan, size, anatomy, and physiology from humans, rodent ADPKD models cannot fully mimic the disease. To obtain a large ani...

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Detalles Bibliográficos
Autores principales:	He, Jin, Li, Qiuyan, Fang, Suyun, Guo, Ying, Liu, Tongxin, Ye, Jianhua, Yu, Zhengquan, Zhang, Ran, Zhao, Yaofeng, Hu, Xiaoxiang, Bai, Xueyuan, Chen, Xiangmei, Li, Ning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366635/ https://www.ncbi.nlm.nih.gov/pubmed/25798056 http://dx.doi.org/10.7150/ijbs.10858

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